UC Davis 2008-2010 General Catalog - General Catalog - UC Davis

408 Molecular and Cellular Biology
123. Behavior and Analysis of Enzyme and
Receptor Systems (3)
Lecture—3 hours. Prerequisite: Biological Sciences
103. Introduction to the principles of enzyme kinetics
and receptor-ligand interactions with emphasis on
metabolic regulation and data analysis. Topics
include simultaneous equilibria, chemical and
steady-state kinetics, allosteric enzymes, mulitreactant
systems, enzyme assays, membrane transport
and computer-assisted simulations and analyses.—I,
III. (I, III.) I. Segel, Wilson
124. Macromolecular Structure and
Function (4)
Lecture—4 hours. Prerequisite: Biological Sciences
103, Chemistry 107B, 118C. An in-depth investigation
into protein and nucleic acid structure and thermodynamics
and how these properties influence
their biological functions. Key examples of important
functional classes of these molecules will be examined.
Not open for credit to students who have completed
course 122 or Chemistry 108.—I, III. (I, III.)
Baldwin, Stahlberg
126. Plant Biochemistry (3)
Lecture—3 hours. Prerequisite: Biological Sciences
103 or 105. The biochemistry of important plant
processes and metabolic pathways. Discussion of
methods used to understand plant processes, including
use of transgenic plants. (Same course as Plant
Biology 126.)—II. (II.) Abel, Callis
138. Undergraduate Seminar in
Biochemistry (1)
Seminar—1 hour. Prerequisite: Biological Sciences
103. Discussion of the historical developments of
modern biochemistry or current major research problems.
May be repeated twice for credit when topic
differs. (P/NP grading only.)—I, II, III. (I, II, III.)
140L. Cell Biology Laboratory (5)
Lecture—2 hours; laboratory—6 hours; discussion—
1 hour. Prerequisite: Biological Sciences 104 (may
be taken concurrently). Exercises illustrating the principles
of cell biology with emphasis on light microscopy.—II.
(II.) Kaplan, Nunnari
142. Advanced Cell Biology: Contractile
and Motile Systems (4)
Lecture—3 hours; term paper. Prerequisite: Biological
Sciences 102, 104 (may be taken concurrently);
Mathematics 16B. Advanced cell biology with
emphasis on molecular, biophysical and cellular
properties of contractile and motile systems.
143. Cell Biophysics (3)
Lecture—3 hours. Prerequisite: Biological Sciences
101, 102, 103, 104. Physical principles underlying
observations and mechanisms of cell motility. Organization
of biomolecules into higher order subcellular
structures that function as macromolecular
machines. Examples include cytoskeletal filaments,
polymer-motor systems, neurites, axonemes and
mitotic spindles.—I. (I.) Scholey
144. Mechanisms of Cell Division (3)
Lecture—3 hours. Prerequisite: Biological Sciences
101, 102, 104. The molecules and mechanisms that
allow eukaryotic cells to coordinate cell growth,
DNA replication, segregation of chromosomes and
cell division.—II. (II.) McNally
145. Assembly and Function of Cell
Signaling Machinery (3)
Lecture—3 hours. Prerequisite: Biological Sciences
101, 102, 104. Molecular basis of cell signaling,
including positioning of cellular machinery, components
of various signaling pathways, and downstream
effects of signaling on cell adhesion, cell
differentiation, and programmed cell death.—III.
(III.) Erickson
148. Undergraduate Seminar in Cell
Biology (2)
Seminar—2 hours. Prerequisite: upper division
standing in the biological sciences or a related discipline.
Student reports on current topics in cell biology
with emphasis on integration of concepts,
synthesis, and state-of-the-art research approaches.
Reviews of literature and reports of undergraduate
research may be included. May be repeated for
credit. (P/NP grading only.)
150. Developmental Biology (4)
Lecture—4 hours. Prerequisite: Biological Sciences
101 and concurrent enrollment in course 150L.
Analysis of the mechanistic basis for animal development
with a focus on experimental evidence and the
relevant fundamental experimental strategies. Fertilization
and early development, morphogenesis and
patterning, cell differentiation, regulation of cell proliferation
and tissue growth.—I. (I.) Armstrong,
Edwards
150L. Laboratory in Developmental Biology
(1)
Laboratory—3 hours. Prerequisite: concurrent enrollment
in course 150. Experiments using live embryos
and histological slide preparations of developing
embryos will be used to investigate and illustrate the
basic mechanisms of animal development. (P/NP
grading only.)—I. (I.) Edwards
158. Undergraduate Seminar in
Developmental Biology (2)
Seminar—2 hours. Prerequisite: upper division
standing in the biological sciences or a related discipline.
Student reports on current topics in cell biology
with emphasis on integration of concepts,
synthesis, and state-of-the-art research approaches.
Reviews of literature and reports of undergraduate
research may be included. May be repeated for
credit. (P/NP grading only.)—I, II, III. (I, II, III.)
160L. Principles of Genetics Laboratory (4)
Laboratory—6 hours; lecture—2 hours. Prerequisite:
Biological Sciences 101. Laboratory work in basic
and molecular genetics including gene mapping and
isolation of mutants. Not open for credit to students
who have completed Genetics 100L.—I, II, III. (I, II,
III.) Britt, Kiger, Kimbrell, Natzle, Rose, Sanders,
Sundaresan
161. Molecular Genetics (3)
Lecture—3 hours. Prerequisite: Biological Sciences
101, Biological Sciences 102 may be taken concurrently.
Molecular mechanisms for propagation and
expression of the genome in eukaryotic and prokaryotic
model organisms. How genetic and molecular
tools, both classical and modern, are applied to the
study of gene structure, function, and regulation. Not
open for credit to students who have completed
course 121.—II. (II.) Burgess, Gasser, Powers
162. Human Genetics (3)
Lecture—3 hours. Prerequisite: course 161 (preferred)
or 121, 164. Human molecular genetic variation,
molecular basis of metabolic disorders,
chromosome aberrations and consequences, analysis
of the human genome, and computational techniques
of genetic analysis.—I. (I.) Chedin, Sanders
163. Developmental Genetics (3)
Lecture—3 hours. Prerequisite: course 161 (preferred)
or 121, course 164. Current aspects of
development genetics. Historical background and
current genetic approaches to the study of development
of higher animals.—II. (II.) Natzle, L. Rose
164. Advanced Eukaryotic Genetics (3)
Lecture—3 hours. Prerequisite: course 161 or 121.
The five basic operations of genetic analysis: mutation,
segregation, recombination, complementation,
and regulation. Emphasis on the theory and practice
of isolating and analyzing mutations, as well as
understanding mechanisms underlying both Medelian
and epigenetic inheritance.—III. (III.) Burgess
178. Undergraduate Seminar in Molecular
Genetics (1)
Seminar—1 hour. Prerequisite: upper division standing,
completion of Biological Sciences 101, course
160L, and completion or concurrent enrollment in
course 161. Discussion of current topics in molecular
genetics to show advanced applications of basic
principles and to highlight professional career
opportunities. May be repeated for credit. (P/NP
grading only.)—I, II, III. (I, II, III.)
182. Principles of Genomics (3)
Lecture—3 hours. Prerequisite: Biological Sciences
101, course 121 or 161. Fundamentals of genomics,
including structural genomics, functional genomics,
proteomics, and bioinformatics, focusing on the
impact of these disciplines on research in the biological
sciences. Social impacts of genomic research.—
III. (III.) Korf
190C. Undergraduate Research Conference
(1)
Discussion—1 hour. Prerequisite: upper division
standing and consent of instructor; concurrent enrollment
in course 193 or 199. Presentation and discussion
of current research by faculty and students. May
be repeated for credit. (P/NP grading only.)—I, II,
III. (I, II, III.)
191. Introduction to Research (1)
Seminar—1 hour. Prerequisite: Biological Sciences
102 (may be taken concurrently) or consent of
instructor. Various topics in molecular and cellular
biology including biochemistry, genetics, and cell
biology will be discussed, along with ways undergraduates
can participate in research projects of faculty
members. May be repeated for credit. (P/NP
grading only.)—I, II, III. (I, II, III.)
192. Internship (1-12)
Internship—3-36 hours. Prerequisite: completion of
84 units and consent of instructor. Technical and/or
practical experience on and off campus, supervised
by a member of the Section of Molecular and Cellular
Biology faculty. (P/NP grading only.)
193. Advanced Research (3)
Laboratory—6 hours; discussion—1 hour. Prerequisite:
upper division standing, completion of an upper
division Molecular and Cellular Biology laboratory
course and consent of instructor. Research project
carried out under the supervision of a faculty sponsor.
Discussion and analysis of results and proposed
experiments on a weekly basis with faculty sponsor.
May include presentation of a seminar to a research
group. May be repeated for credit. (P/NP grading
only.)—I, II, III. (I, II, III.)
194H. Research Honors (3)
Independent study—9 hours. Prerequisite: 6 units of
course 193 and/or 199 with faculty director; senior
standing; GPA of at least 3.250; consent of Section.
Honors project. Continuation of an intensive, individual
laboratory research project in biochemistry,
genetics, or cell biology culminating with the presentation
of the work in a written thesis and in a seminar.
(P/NP grading only.)
197T. Tutoring in Molecular and Cellular
Biology (1-5)
Tutorial—2-6 hours. Prerequisite: upper division
standing, completion of course to be tutored, and
consent of instructor. Assisting the instructor in one of
the section’s regular courses by tutoring individual or
small groups of students in a laboratory, in voluntary
discussion groups, or other voluntary course activities.
May be repeated for credit. (P/NP grading
only.)—I, II, III. (I, II, III,)
198. Directed Group Study (1-5)
Variable—1-5 hours. Prerequisite: consent of instructor.
(P/NP grading only.)
199. Special Study for Advanced
Undergraduates (1-5)
Independent study—3-15 hours. Prerequisite: consent
of instructor. (P/NP grading only.)
Graduate Courses
200A. Current Techniques in Cell Biology (2)
Lecture—2 hours. Prerequisite: graduate standing;
Biological Sciences 104 and course 141 or the
equivalent courses. Current techniques used in cell
biology research including microscopy, spectroscopy,
electrophysiology, immunochemistry, histology,
organelle isolation, calorimetry, tissue culture and
gel electrophoresis. Lectures are presented by
experts on each technique, with an emphasis on pitfalls
to avoid when using the technique. (Same
course as Cell and Developmental Biology 200.) (S/
U grading only.)—I. (I.) Beck
200B. Current Techniques in Biochemistry
(2)
Lecture—2 hours. Prerequisite: Biological Sciences
103 and course 120L or the equivalent. Current
techniques used in biochemical research including
protein and carbohydrate analyses, immunochemis-
Quarter Offered: I=Fall, II=Winter, III=Spring, IV=Summer; 2009-2010 offering in parentheses
General Education (GE) credit: ArtHum=Arts and Humanities; SciEng=Science and Engineering; SocSci=Social Sciences; Div=Social-Cultural Diversity; Wrt=Writing Experience