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UC Davis 2008-2010 General Catalog - General Catalog - UC Davis

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Molecular, Cellular, and Integrative Physiology (A Graduate Group) 409<br />

try, recombinant DNA methods, electrophoretic and<br />

chromatographic methods. (S/U grading only.)—II.<br />

(II.) Kaplan<br />

200C. Current Techniques in Biophysics (2)<br />

Lecture—2 hours. Prerequisite: graduate standing;<br />

Biological Sciences 102 or 104 or the equivalent.<br />

Current techniques in biophysics research including<br />

diffraction, magnetic resonance spectroscopy, calorimetry,<br />

optical spectroscopy, and electrophysiology.<br />

(Same course as Biophysics Graduate Group 200.)<br />

(S/U grading only.)—II. (II.)<br />

220L. Advanced Biochemistry Laboratory<br />

Rotations (5)<br />

Laboratory—15 hours. Prerequisite: course 221A<br />

(may be taken concurrently) and 120L or the equivalent.<br />

Two five-week assignments in biochemistry<br />

research laboratories. Individual research problems<br />

with emphasis on methodological/procedural experience<br />

and experimental design. May be repeated<br />

twice for credit.—I, II, III. (I, II, III.) Chedin, Trimmer<br />

221A. Physical Biochemistry (4)<br />

Lecture—4 hours. Prerequisite: Biological Sciences<br />

103, Chemistry 107B, 108, and 128C, 129C, or<br />

118C or the equivalent or consent of instructor.<br />

Chemical and physical properties of biomacromolecules<br />

emphasizing the interrelationship of molecular<br />

interactions and thermodynamic properties as determinants<br />

of higher order structure. The use of NMR<br />

and crystallography in determining macromolecular<br />

structure.—I. (I.) Baldwin, Stahlberg, D. Wilson<br />

221B. Mechanistic Enzymology (3)<br />

Lecture—3 hours. Prerequisite: undergraduate level<br />

organic and biological chemistry, one course in<br />

physical chemistry recommended. Analysis of<br />

organic enzyme reaction mechanisms and the exploration<br />

of enzyme catalyzed reactions.—I. (I.) Baldwin,<br />

Fiehn, Toney<br />

221C. Molecular Biology (4)<br />

Lecture—4 hours. Prerequisite: course 221A or the<br />

equivalent. Pass 1 restricted to graduate students in<br />

biochemistry and molecular biology, microbiology,<br />

or genetics. Structure and organization of DNA and<br />

chromatin; DNA replication, repair and recombination;<br />

transcription and RNA processing; protein biosynthesis<br />

and turnover; transcriptional and posttranscriptional<br />

control mechanisms; examples from<br />

eukaryotic and eubacterial cells, and viruses. (Same<br />

course as Genetics 201C.)—III. (III.) Baldwin, H.<br />

Chen, Heyer, Korf, Stewart<br />

221D. Cellular Biochemistry (4)<br />

Lecture—3 hours; discussion—1 hour. Prerequisite:<br />

Biological Sciences 102, course 221A or the equivalent<br />

or consent of instructor. Molecular structure and<br />

biophysical properties of cell membranes; organelle<br />

biogenesis and trafficking; signal transduction,<br />

metabolism and metabolic regulation; cytoplasmic<br />

organization, biophysics of the cytoskeleton and<br />

force-generating mechanisms, mechanism of intracellular<br />

transport and mitosis; cell reproduction and the<br />

cell cycle.—II. (II.) McNally, Nunnari, Powers,<br />

Scholey, Starr<br />

241. Membrane Biology (3)<br />

Lecture—3 hours. Prerequisite: Biological Sciences<br />

102, 103, 104 or consent of instructor. Advanced<br />

topics on membrane biochemistry and biophysics.<br />

Relationship of the unique properties of biomembranes<br />

to their roles in cell biology and physiology.<br />

(Same course as Biophysics 241.)—III. (III.) Longo,<br />

Voss<br />

248. Seminar in Cell Biology (2)<br />

Seminar—2 hours. Prerequisite: consent of instructor.<br />

Discussion of recent literature on the physical and<br />

chemical aspects of organization and function of living<br />

systems, topics of current interest in ultrastructure<br />

and function of cells. Organizational and functional<br />

properties of the molecular and cellular levels of biological<br />

systems. May be repeated for credit.—I.<br />

Myles<br />

251. Molecular Mechanisms in Early<br />

Development (3)<br />

Lecture—3 hours. Prerequisite: graduate standing or<br />

consent of instructor; introductory background in<br />

developmental biology and/or cell biology recommended.<br />

Analysis of the early events of development<br />

including: germ cells and other stem cells, gametogenesis,<br />

meiosis, imprinting, fertilization, geneticallyengineered<br />

organisms, egg activation and establishment<br />

of embryonic polarity with focus on cellular<br />

events including gene regulation and cell signaling.<br />

Offered in alternate years.—(I.) Myles<br />

252. Cellular Basis of Morphogenesis (4)<br />

Lecture/discussion—3 hours; term paper. Prerequisite:<br />

course 150. Development of form and structure;<br />

morphogenetic movement, mechanisms of cellular<br />

motility, cell adhesion, intercellular invasion, interaction<br />

of cells and tissues in development. Offered in<br />

alternate years.—(II.) Armstrong, Tucker<br />

255. Molecular Mechanisms in Pattern<br />

Formation and Development (3)<br />

Lecture—3 hours. Prerequisite: graduate standing or<br />

consent of instructor; introductory background in<br />

developmental biology and/or genetics recommended.<br />

Genetic and molecular analysis of mechanisms<br />

that control animal development after<br />

fertilization. Establishment of embryonic axes, cell<br />

fate and embryonic pattern; induction, apoptosis, tissue<br />

patterning. Critical reading of current literature<br />

in C.elegans, Drosophila, and mouse genetic model<br />

systems. Offered in alternate years.—III. Natzle,<br />

Rose<br />

256. Cell and Molecular Biology of Cancer<br />

(2)<br />

Lecture—1 hour; term paper. Prerequisite: course in<br />

cell or developmental biology (e.g., course 150,<br />

141, 163, or Biological Sciences 104). Analysis at<br />

the cellular and molecular levels of the regulation of<br />

normal and neoplastic tissue growth; tumor dissemination;<br />

identification and characterization of oncogenic<br />

agents; characterization of oncogenes and<br />

tumor-suppressor genes.—I. (I.) Armstrong<br />

257. Cell Proliferation and Cancer Genes<br />

(3)<br />

Lecture—1.5 hours; seminar—1.5 hours. Prerequisite:<br />

course 221C and 221D or the equivalent.<br />

Genetic and molecular alterations underlying the<br />

conversion of normal cells to cancers, emphasizing<br />

regulatory mechanisms and pathways. Critical reading<br />

of the current literature and development of<br />

experimental approaches.—I. (I.) Carraway, Radke<br />

258. Seminar in Development (2)<br />

Seminar—2 hours. Prerequisite: consent of instructor.<br />

Reports and discussion on embryology, morphogenesis,<br />

and developmental mechanisms. May be<br />

repeated for credit.—II. (II.) Armstrong, Erickson<br />

259. Literature in Developmental Biology<br />

(1)<br />

Seminar—1 hour. Prerequisite: consent of instructor.<br />

Critical presentation and analysis of recent journal<br />

articles in developmental biology. May be repeated<br />

for credit. (S/U grading only.)—I, II, III. (I, II, III.)<br />

Armstrong, Erickson, Myles<br />

263. Biotechnology Fundamentals and<br />

Application (2)<br />

Lecture—2 hours. Prerequisite: Biological Sciences<br />

101, 102, Microbiology 102, graduate student in<br />

good standing. To train graduate students interested<br />

in a biotechnology career track; to learn recombinant<br />

DNA, rate processes of biological systems, optimization<br />

of bioreactor performance, practical issues<br />

in biotechnology, and some case studies of the<br />

development of biotechnology products and processes.<br />

Offered in alternate years.—II. (II.) McDonald,<br />

Privalsky, Rodriguez, Vandergheynst<br />

282. Biotechnology Internship (7-12)<br />

Internship—21-36 hours. Prerequisite: graduate<br />

standing and consent of instructor. Research at a biotechnology<br />

company or interdisciplinary cross-college<br />

lab for a minimum of 3 months as part of the<br />

Designated Emphasis in Biotechnology Program. (S/<br />

U grading only.)—I, II, III. (I, II, III.) Dandekar<br />

290C. Research Conference (1)<br />

Discussion—1 hour. Prerequisite: graduate standing<br />

and consent of instructor. Presentations and critical<br />

discussions of faculty and graduate student research<br />

in molecular and cellular biology including biochemistry,<br />

genetics, and cell biology. May be repeated<br />

for credit. (S/U grading only.)—I, II, III. (I, II, III.)<br />

291. Current Progress in Molecular and<br />

Cellular Biology (1)<br />

Seminar—1 hour. Prerequisite: graduate standing or<br />

consent of instructor. Seminars presented by guest<br />

lecturers on subject of their own research activities.<br />

May be repeated for credit. (S/U grading only.)—I,<br />

II, III. (I, II, III.) Draper<br />

294. Current Progress in Biotechnology (1)<br />

Seminar—1 hour. Prerequisite: graduate standing or<br />

consent of instructor. Seminars presented by guest<br />

lecturers on subjects of their own research activities.<br />

May be repeated for credit. (Same course as Chemical<br />

Engineering 294.) (S/U grading only.)—I, II, III.<br />

(I, II, III.) Kjelstrom, McDonald, Rodriguez<br />

295. Literature in Molecular and Cellular<br />

Biology (1)<br />

Seminar—1 hour. Prerequisite: graduate standing<br />

and consent of instructor. Critical reading and evaluation<br />

of current literature in molecular and cellular<br />

biology disciplines. Papers will be presented and<br />

discussed in detail. May be repeated for credit. (S/<br />

U grading only.)—I, II, III. (I, II, III.) Baldwin, Fisher,<br />

Myles, Privalsky, Radke, Wilson<br />

298. Group Study (1-5)<br />

Variable—1-5 hours. Prerequisite: consent of instructor.<br />

(S/U grading only.)<br />

299. Research (1-12)<br />

Independent study—3-36 hours. (S/U grading only.)<br />

Professional Course<br />

390. Methods of Teaching (1)<br />

Discussion—1 hour. Prerequisite: graduate standing<br />

and consent of instructor. Practical experience in the<br />

methods and problems of teaching biochemistry/<br />

genetics/cell biology. Includes analysis of texts and<br />

supporting material, discussion of teaching techniques,<br />

preparing for and conducting discussion and<br />

laboratory sections, formulating examinations under<br />

supervision of instructor. Participating in the teaching<br />

program required for Ph.D. May be repeated for<br />

credit. (S/U grading only.)—I, II, III. (I, II, III.)<br />

Molecular, Cellular,<br />

and Integrative<br />

Physiology (A<br />

Graduate Group)<br />

Catherine VandeVoort, Ph.D., Chairperson of the<br />

Group<br />

Group Office. 313 Life Sciences<br />

(530) 752-9092;<br />

http://biosci2.ucdavis.edu/ggc/mcip/<br />

Faculty<br />

Thomas Sean H. Adams, Ph.D., Research<br />

Physiologist (USDA WHNRC)<br />

Thomas E. Adams, Ph.D., Professor (Animal Science)<br />

Steven E. Anderson, Ph.D., Associate Researcher<br />

(Physiology and Membrane Biology)<br />

Joseph F. Antognini, M.D., Professor<br />

(Anesthesiology and Pain Medicine)<br />

Trish J. Berger, Ph.D., Professor (Animal Science)<br />

Bers, Donald M., Ph.D., Professor<br />

(Medical Pharmacology)<br />

Sue Bodine, Ph.D., Professor (Exercise Science)<br />

Ann C. Bonham, Ph.D., Professor<br />

(Medical Pharmacology and Toxicology)<br />

Laura Borodinsky, Ph.D., Assistant Professor<br />

(Physiology & Membrane Biology)<br />

Robert Brosnan, Ph.D., Assistant Professor<br />

(VM: Surgical & Radiological Sciences)<br />

Peter M. Cala, Ph.D., Professor<br />

(Physiology and Membrane Biology)<br />

Christopher C. Calvert, Ph.D., Professor<br />

(Animal Science)<br />

Quarter Offered: I=Fall, II=Winter, III=Spring, IV=Summer; 2009-<strong>2010</strong> offering in parentheses<br />

<strong>General</strong> Education (GE) credit: ArtHum=Arts and Humanities; SciEng=Science and Engineering; SocSci=Social Sciences; Div=Social-Cultural Diversity; Wrt=Writing Experience

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