Clinical Biochemistry of Domestic Animals (Sixth Edition) - UMK ...

References
511
were reported to occur in 67%, 77%, 96%, 63%, and 75%
of cases, respectively ( Arthur et al. , 1986 ).
D . Fanconi-Like Syndromes
Fanconi-like syndromes are observed in some breeds of
dogs, mainly basenjis ( Noonan and Kay, 1990 ). They are
characterized by multiple defects in the reabsorption of
glucose, sodium, potassium, calcium, phosphate, amino
acids, and water by the tubule ( Bovee et al. , 1979 ; Settles
and Schmidt, 1994 ) producing decreased U-SG, proteinuria,
and glucosuria ( Darrigrand-Haag et al. , 1996 ; Easley
and Breitschwerdt, 1976 ). They may also be acquired
as a result of gentamicin toxicity ( Brown et al. , 1986 ) or
calcitriol deficiency ( Freeman et al. , 1994 ), they may be
experimentally produced by maleic acid ( Al-Bander et al. ,
1985 ) or 4-pentaenoate administration ( Gougoux et al. ,
1989 ), or they may be transient and of unknown etiology
( Hostutler et al. , 2004 ; Jamieson and Chandler, 2001 ).
GFR in dogs with Fanconi-like syndrome may be
decreased or remained unchanged ( Bovee et al. , 1979 ;
Breitschwerdt et al. , 1983). Glucosuria, which is one of the
major findings in Fanconi-like syndromes, was not correlated
with a reduction in GFR or with defective reabsorption
of phosphate and sodium (Bovee et al. , 1978a,b). The
cause of death is apparently not progressive nonspecific
renal failure, as the final events are papillary necrosis and
pyelonephritis ( Bovee et al. , 1978b, 1979 ).
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