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Clinical Biochemistry of Domestic Animals (Sixth Edition) - UMK ...

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Chapter 28<br />

Avian <strong>Clinical</strong> <strong>Biochemistry</strong><br />

J. T. Lumeij<br />

Department <strong>of</strong> <strong>Clinical</strong> Sciences <strong>of</strong> Companion <strong>Animals</strong><br />

Faculty <strong>of</strong> Veterinary Medicine<br />

Utrecht, University<br />

Utrecht, The Netherlands<br />

I. INTRODUCTION<br />

II. COLLECTION OF BLOOD SAMPLES<br />

A. Size <strong>of</strong> Blood Samples<br />

B. Handling <strong>of</strong> Blood Samples<br />

C. Sampling Procedure<br />

III. STARVATION, FLIGHT, AND POSTPRANDIAL<br />

EFFECTS: CIRCADIAN AND CIRCANNUAL RHYTHMS<br />

A. Introduction<br />

B. <strong>Biochemistry</strong> <strong>of</strong> Long-Term Starvation<br />

C. <strong>Biochemistry</strong> <strong>of</strong> Endurance Flight<br />

IV. PLASMA PROTEINS<br />

A. Introduction<br />

B. Plasma versus Serum<br />

C. Physiological Variation in Female Birds<br />

D. Refractometry versus the Biuret Method<br />

E. Effect <strong>of</strong> Protein Standards<br />

F. Plasma Protein Electrophoresis: Albumin/Globulin<br />

Ratio<br />

G. Albumin Methodology<br />

H. Prealbumin<br />

V. RENAL FUNCTION<br />

A. End Products <strong>of</strong> Protein Metabolism: Hyperuricemia<br />

and Gout<br />

B. Articular and Visceral Gout<br />

C. Acute versus Chronic Renal Failure<br />

D. Prerenal Azotemia<br />

E. Urea versus BUN<br />

F. Postprandial Effects<br />

G. Other Changes Associated with Renal Failure<br />

H. Murexide Test<br />

I. Birefringent Crystals<br />

VI. HEPATOBILIARY DISEASE<br />

A. <strong>Clinical</strong> Enzymology<br />

B. Enzyme Activities in Avian Tissues<br />

C. Clearance <strong>of</strong> Enzymes from Plasma<br />

D. Experimentally Induced Liver and Muscle Disease<br />

E. Bile Pigments<br />

F. Bile Acids<br />

G. Postprandial Effects<br />

H. Plasma Ammonia: Hepatoencephalopathy<br />

I. Exogenous Markers<br />

J. Iron Storage Disease<br />

K. <strong>Clinical</strong> Diagnosis <strong>of</strong> Liver Disease<br />

VII. MUSCLE DISEASE<br />

VIII. CALCIUM AND PHOSPHORUS: METABOLIC BONE<br />

DISEASE<br />

A. Relation between Calcium and Protein in Avian<br />

Plasma<br />

B . Hypercalcemia<br />

C. Physiological Marrow Ossification<br />

D. Hypocalcemia Syndrome in African Grey Parrots<br />

E. Alkaline Phosphatase in Bone Disease<br />

IX. DIABETES MELLITUS AND PLASMA GLUCOSE<br />

X. EXOCRINE PANCREATIC DISEASE<br />

XI. TOXICOLOGY<br />

A. Le ad<br />

B. Zi nc<br />

C. Organophosphate and Carbamate<br />

XII. BLOOD COAGULATION<br />

A. Introduction<br />

B. Normal Hemostasis in Birds<br />

C. Diagnostic Tests<br />

D. Hemostatic Disorders<br />

ACKNOWLEDGMENTS<br />

REFERENCES<br />

I . INTRODUCTION<br />

Avian medicine and surgery have been recognized as an<br />

<strong>of</strong>ficial specialty in veterinary medicine on three continents<br />

(Europe, Australia, and North America). The increasing<br />

demand for veterinary care for individual birds with a high<br />

sentimental or economical value and efforts to conserve<br />

endangered species facilitated this awareness. The commercial<br />

poultry flock approach to diagnosis, utilizing necropsy as<br />

<strong>Clinical</strong> <strong>Biochemistry</strong> <strong>of</strong> <strong>Domestic</strong> <strong>Animals</strong>, 6th <strong>Edition</strong> 839<br />

Copyright © 2008, Elsevier Inc.<br />

All rights reserved.

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