Clinical Biochemistry of Domestic Animals (Sixth Edition) - UMK ...

VI. Lipoproteins
93
TABLE 4-2 Apolipoproteins of Domestic Animals
a
Molecular
Apolipoprotein Weight Organ
Major
Synthetic
Lipoprotein
Constituent of
Special Properties
A-I 28 kd (all species) Small intestine Chylomicrons, HDL Activates lecithin: cholesterol
acyltransferase
A-II (monomer) 8.5 kd (cattle, dog) Small intestine Chylomicrons, HDL Exists mostly as a dimer
6.5 kd (horse)
A-IV 43 kd (cattle, dog) Small intestine Nascent chylomicrons, HDL Activates lecithin: cholesterol
acyltransferase
B 48 270 kd (cattle, horse) Small intestine Chylomicrons
B 100 534 kd (cattle, horse) Liver VLDL, LDL Binds to LDL receptor 325 kd
(swine)
C-I 8.0 kd (cattle) Liver VLDL, LDL, HDL, chylomicrons
C-II 9.5 kd (cattle, pig) Liver VLDL, LDL, HDL, chylomicrons Activator of lipoprotein lipase
C-III
14 kd (horse)
8.0 kd (cattle)
12 kd (horse)
Liver
VLDL, LDL, HDL
C-IV 10 kd (cattle) Liver VLDL, LDL, HDL, chylomicrons
E 37 kd (all species) Liver VLDL, LDL, HDL, chylomicrons Binds to LDL and
chylomicron remnant receptor
a
From Bauchart (1993) , Chapman (1986) , Demacker et al . (1987) , Watson et al . (1991) , and Watson and Barrie (1993) .
FIGURE 4-6 Metabolism and transport of chylomicrons. Abbreviations: A, B 48 , C, E, apolipoproteins; HDL,
high-density lipoprotein; TAG, triacylglycerol.