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Part-IResults and Discussion3.2.2 Synthesis of 2-chloromethyl-5-substituted-7-phenylpyrazolo[4,3-d]pyrimidin-4(3H)-one (IIxviii)However, when o-aminoester of the nitrogen containing heterocycle pyrazole was tried tocyclize with nitriles under acidic conditions, the reaction failed to proceed. Somodification was done by preparing pyrazole o-aminoamides as the starting material andreacted with chloroacetylchloride 26 in presence of potassium carbonate and cyclized insitu in presence of water to get the corresponding 2-chlormethyl derivative (Scheme-16).OOSOC 2 H 5SNHClNNNH 2 +NCl1, 4-dioxanex0-5 o CNNN22OIxviiOIIxviiiOSNNNH 2NH 2ClO26 Cl NK 2 CO 3 /DMF,0 o C, 2hSNNHNH 2Cl-H 2 OStirring, RT, 8-10 hOSNNNNHClIxviiIIxviiiScheme-1680