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2.5. Drawbacks associated with MWIPart-IIImpact of Microwave…1. One of the major drawbacks of this relatively new technology is equipment.Although prices for dedicated microwave reactors for organic synthesis havedropped considerably since their first introduction in the late 1990s, the currentprice range for microwave reactors is still many times higher than that ofconventional heating equipment cost, ranging from US$15,000-100,000.2. An even bigger problem, especially for the drug discovery industry, is scalability.It has to be noted that with few exceptions most of the examples of microwaveassistedsynthesis published so far were carried out on a small scale (1,000 kg), which isa clear limitation of this otherwise so successful technology.Despite these limitations, microwave chemistry has opened up several new avenues inorganic synthesis. Many reactions that previously were not possible, or resulted in a lowyield, can now often be performed quickly, safely and efficiently in a few minutes. Insummary, Microwave Assisted Organic Synthesis has changed the world of organicchemistry and drug discovery, and it would be wise to embrace this new technology or beleft lagging behind with conventional heating methodologies.306