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Part-1Review on Antiulcer LiteratureNH 2NSNSSPI 447 50A series of 1-aryl-3-substitued pyrrolo[3,2-c]quinolines 51, have been found to beinhibitor of H + /K + -ATPase. In vitro H + /K + -ATPase inhibitory activity was dependent onthe substituents at the 3-posotion of the pyrrolo[3,2-c]quinolines, whereas 1-arylsubstituents affected the in vivo gastric acid secretion. 87R 1 NR 2NR 3R 4 51Niiyama et al., 88 have synthesized novel 4-substituted pyridine derivatives like 4-alkoxy-,4-alkylthio and 4-aryloxy-5-methyl-2-[1-(hydroxymethyl)-2-(1-napthyl)-ethyl (ethenyl)]pyridine 52 which were found to have reversible inhibitory activity against H + /K + -ATPase.ORNHO52Kinoshita, et al., 89 have reported a be novel reversible PPI, 2-[(2-dimethylaminobenzyl)sulfinyl]-1-(3-methylpyridine-2-yl-)imidazole53 (T-330), which was foundto possess, anti-secretory activity more potent than omeprazole and ranitidine.32