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Part-1Review on Antiulcer Literaturereversible inhibitors of H + /K + -ATPase. Although, highly efficacious drugs could emergefrom research on APAs. 501.7. Reports on the Continuing Research and Development on Different PPIs1.7.1. Irreversible Inhibitors; Related to OmeprazoleK. Uchiyama, et al., 72 have reported the synthesis of (+/-) 5-methoxy-2-[(4-methoxy-3,5-dimethyl-pyridin-2-yl)methylsulfinyl]-1H-imidazo[4,5-b]pyridine, (TU-199) 33 and itseffect on histamine, carbachol and tetragastrin stimulated gastric acid secretion. Theyhave claimed it to be having more potent and long lasting effect on gastric acid secretionvia inhibition of H + /K + -ATPase than omeprazole.NOSNONNHTU-199 33O1.7.1.1. Changes Made on/in Benzimidazole Nucleus:Changes have been made on the benzimidazole nucleus without loss of activity.Following are some reports:Woo et al 73 ., have reported the biological evaluation of 2-[3-(2,3-dihydro-1H-pyrolo[1,2-a]benzimidazolyl)sulfinyl]-5-methyl-1H-benzimidazoles, (YJA20379-4) 34 whichhad marked inhibitory effect on H + /K + -ATPase. YJA20379-4 also exhibited anti-H. pyloriactivity 3 times higher than omeprazole along with the enhancement of mucosal defense,thus, indicating a wide spectrum of anti-ulcer activities. In another related work, Kim, etal., 74 modified, 34, by fusing imidazopyridines with thiazolopyridines to get YJA-20379-2. 35. This compound not only suppressed H + /K + -ATPase activity, but also hadsignificant reinforcing activity on the defensive factors.26