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List of TablesTableNo.TitlePageNo.Part-I1. Some landmarks in therapy of acid-peptic disorders in past 35 years 22. Distinguishing features of two major forms of peptic ulcers 53. Pharmacological properties of the different proton pump inhibitors 244. Modifications reported in the PMSB nucleus 595. Proposed series of compounds synthesized for biological evaluation 636. Physical data of 2-amino-3-carbethoxythiophenes (Ii-xii) synthesized 717. Physical data of other o-aminoesters (Ixiii-xvii) synthesized 778. Physical data of condensed 2-chloromethylpyrimidin-4(3H)-ones (IIi-xviii) 81synthesized9. Physical data of condensed pyrimidines with 2-mercapto-benzimidazole 86(IIIi-xxxv) synthesized10. Physical data of condensed pyrimidines sulfinyl derivatives (IVi-xxxv) 94synthesized11. Effect of newly synthesized proton pump inhibitors on gastric secretion and 121antiulcer activity in Shay rat model12. List of the physicochemical descriptors available in the software. 14613. Observed and predicted biological activities of the molecules under study. 15014. Observed and predicted biological activities of training set of molecules. 15215. Observed and predicted biological activities of training set of molecules. 15316. Observed and predicted biological activities of the molecules under study. 15517. Observed and predicted biological activities the molecules under study. 15618. Observed and predicted biological activities of the molecules under study. 15819a. Properties of the most active and most inactive molecules used in the study 159and their comparison with currently used drug.19b. List of QSAR equations developed for the both series of compounds under 161study.Part-II20. 2-Substitutedquinazolin-4(3H)-ones 22721. 2-Substituted thieno[2,3-d]pyrimidin-4(3H)-ones 229ix