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Part-IIIAdvances Dihydropyridines and …OONO 2OOOH 3 CCH 3 H 3 CCH 3H 3 C N CH 3H 3 C N CHH3H75 69OOOH 3 C NHCH 381Figure-13. Structures of active DP DHPsIn an attempt to further modify the DP7, various modifications were done, particularly onC-5 benzoyl group and C-4 phenyl ring as in HK series 82. 113R 2OOR 1H 3 C N CH 3HHK series 32R 1 - Cl, CH 3 , OCH 3R 2 = 2-Cl, 3-Cl, 4-Cl, 4-OH, 4-CH 3 , 4-OCH 3 ,phenoxy, 2,5-dimethoxy, 2-NO 2 , 3-NO 2 , 3-Br etc.Figure-14. Common structure of HK series DHPsIn a recent study by Azizi E et al., the work apparently initiated on basis of results fromDP series, new series of DHPs modified at C-4 position carrying 1,3-thiazole substitutedat C-2 has been investigated for inhibitory effects on cell proliferation of parental andmoderately resistant T47D breast cancer cells. New DHPs were also studied for theireffects on MDR1 reversal agent in these breast cancer cells and compared to verapamil as420