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Part-IResults and DiscussionOONHNSOHNNSOOmeprazoleONHONHR 129aR 1R 2 R 2NNR 3NHNXSNot possibleXOR 3HNNSOPyrimidineNHNHScheme-29However, it may abstract the proton of the sulfhydryl group of the cysteine 813 andcysteine 822 of the H + /K + -ATPase (proton pump) at its imidazolyl nitrogen. Thus,temporarily deprotonating the amino acid residue of the H + /K + -ATPase and makes itineffective (Scheme-30).However, in the presence of the SH group of the Cysteines in its protonated form, themolecules can still loose the molecules of H 2 O and form an ionic bonding with thecysteine as depicted in scheme-30. But this is quite reversible and thus the effect is shortlived.138