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Part-1Review on Antiulcer LiteratureNNNSNGYKI 34655 471.7.3. Reversible Inhibitors (Acid Pump Antagonists)Cheon, et al., 85 have reported the activity of 1-(2-methyl-4-methoxyphenyl)-4-[(3-hydroxypropyl)amino]-6-methyl-2,3-dihydropyrrolo[3,2-c]quinoline (DBM-819) 48 aspotential reversible inhibitor. DBM-819 successfully reduced histamine and pentagastrinstimulated gastric acid secretion and protected against gastric lesions induced by ethanol,NaOH, indomethacin and aspirin, suggesting that DBM-819 acts as an effective anti-ulceragent in vivo. The same workers have also evaluated 1-(2-methyl-4-methoxyphenyl)-4-[(2-hydroxyethyl)amino]-6-trifluoroethoxy-2,3-dihydropyrrolo[3,2-c] quinoline (AU-461)49, which was found to be reversible and competitive inhibitor with respect to theactivating K + cation. 86OONNNNHDBM 819 48OHF 3 CONAU 461 49NHOH3-Amino-5-methyl-2(2-methyl-3-theinyl)-imidazo[1,2-a]thieno[3,2-c]pyridine (SPI-447)50 have also been studied as a reversible inhibitor of proton pump. SPI-447 had no effecton Na + /K + -ATPase activity and was K + competitive inhibitor of H + /K + -ATPase similar toSCH28080 23. 6931