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Part-IResults and DiscussionOther screened compounds did not show significant improvement in the pH of the gastricjuice. But, despite of low pH and high total acidity value, some of the tested compounds(IVviii, IVxi, IVxv, IVxvii, IVxviii, IVxix, IVxxi, IVxxv, IVxxviii, and IVxxix) have theability to protect the stomach from the ulceration as indicated by the low values of ulcerscores, may be because of some other mechanism of protecting gastric mucosa.Suggested Proton Pump Inhibitor mechanism of the test compounds:In normal irreversible PPI’s, the pyridinylmethylsulfinylbenzimidazoles (e.g.,Omeprazole, pentaprazole, rabiprazole etc.) the mechanism of action is depicted asbelow:R 2 OR 3 R 4R 2 OR 3 R 4R 2 OR 3 R 4R 2 OR 3 R 4NH + (Slow)NN-H 2 ONNSOHNSONNHSOHNNSNHNHR 129 29aR 1R 1R 1Oxidation(liver)29bRSHRS -29cR 2 OR 3 R 4R 2 OR 3 R 4R 2 OR 3 R 4NNNR 1SNN-RS -SHNHR 1NNNHR 1SSR29g29fScheme-2829d; R = CH 2 CH 2 OH29e; R = EnzymeInitial acid catalyzed transformation of pyridinylmethylsulfinyl benzimidazoles 29 to thesulfenamide 29c isomers is outlined in scheme-28. The reaction is reversible and goes viaa spiro intermediate, 29a and the sulfenic acid 29b. The reversibility was firmly proved136