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Part-1Review on Antiulcer LiteratureONH 2NH 2OHNNClNOHOCl74Hirosada et.al., 108 reported gastric secretion inhibiting activity of spiro compounds withnovel skeleton 75. These compounds were found to be of value as anti-ulcer, antiinflammatoryand as analgesic.OOO75Otsubo et al., 109 synthesized the enantiomers of 2-(4-chlorobenzoylamino)-3-[2(1H)-quinolinon-4-yl]propionic acid 76, new antiulcer agent that enhances mucosal resistanceThe (+) isomer, rebamipide, was about 1.7 times as potent as the (-)-isomer in antiulceractivity against ethanol-induced gastric ulcers.HNOClHNOOH76OMiki, et al., 110 have synthesized derivatives of benzamide, 77 which have exhibitedexcellent inhibitory effects on several gastric models such as alcohol ulcer, indomethacinulcer, aspirin ulcer and stress ulcer. Also, these compounds exhibited an inhibitory effecton duodenal ulcer models such as cysteamine ulcer and dulcerozine ulcer.40