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Part-IISynthesis of PyrimidinesOH 3 COOC 2 H 5H 3 COH 3 CONH 2NHNNOH 3 CO NH 2MeSCN dry HClMeSCNdry HClDry HClOOH 3 COH 3 COHNNHNHN SCH 3M.W.IH 3 COH 3 CONNSCH 3NH 2H 3 COH 3 CONNNH 2NNOOOH 3 CONHH 3 CONRoute-iH 3 COOOClPTCNONNHH 3 CONNH 2SCH 3HNNOORoute-iiH 3 CONHH 3 CONNONH 2DMF-POCl 30-5 o CNH 3 CONH 3 COClNOH 3 CONNNOH 3 CONNO37ONaN 3AzidationNN 3OZn/AcOHH 3 CONH 3 CONNONRoute-iiiOScheme 12The potential of this reaction for parallel synthesis by judiciously modifying the reactionconditions to generate novel libraries of NCE’s of pyrimidine and condensed pyrimidinesis also quite good. With the successful application MWI in speeding up this reaction, thepotential of this reaction for the parallel synthesis of NCE’s is much more.A few limitations to this reaction, especially its inability to proceed to completion with afew typical o-aminocarbonyl substrates are noted below.This one-pot, hydrogen chloride catalyzed reaction has found to fail with the o-aminocarbonyl substrates of 1, 2, 3-triazole 38, pyrazole 39, and pyrimidine 40.266