Download (4Mb) - Etheses - Saurashtra University

Part-IIContentsNovel Microwave Assisted Green Chemical Synthesis of Condensed 2-Substitutedpyrimidin-4(3H)-ones under Solvent Free Conditions, their MWIAssisted Facile and Rapid Chlorination and their Multidrug Reverting Activity1. Synthesis of pyrimidines and condensed pyrimidines through reactions of nitrileswith ortho-aminocarbonyl substrates under acidic conditions: A Review1.1 Introduction 2201.2 Synthesis of condensed pyrimidines: general aspects 2201.3 Reactions of nitriles under acidic conditions 2221.4 Synthesis of various condensed pyrimidines under the influence of dry 225HCl gas1.5 Investigations in the reaction mechanisms for product formation, 253disproportionations, as well as, isolation and cyclizations of intermediatesinvolved1.6 Synthesis of various mononuclear pyrimidines under the influence of dry 259HCl gas1.7 Synthesis of condensed 4-oxopyrimidines by novel acid catalyzed 261microwave assisted reaction of nitriles with o-aminoesters under solventfree conditions1.8 Scope and limitations 2641.9 Conclusion 2671.10 References 2682. Impact of microwave assisted heating on the combinatorial and parallel syntheses ofcompound libraries for new drug discovery research: A Review2.1 Introduction 2722.2 Theory of microwave assisted heating 2732.2.1 Dielectric properties 2742.2.2 Microwave versus conventional thermal heating 2742.3. Applications of MWI in combinatorial parallel syntheses of compounds 275for new drug discovery research2.3.1 Library synthesis of acyclic and heterocyclic NCE’s 2752.3.2 Library syntheses of mononuclear and condensed pyrimidines 296through MWI