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Download (4Mb) - Etheses - Saurashtra University

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Part-IResults and DiscussionTable-19b. List of QSAR equations developed for the 5-H benzimidazole and 5-methoxybenzimidazole series of compounds under study.S.Total Acidity Volume of Gastric Secretion Ulcer ScoreNo.For H-Benzimidazole series1. Acidity log(1/C) =+0.0044(±0.0000)Quadrupole2-0.0792(± 0.0121)T_C_O_2+0.1386(±0.0547)chi4pathCluster-1.9411andAcidity log(1/C) =-0.0703(± 0.0398)logP -1.5503Volume log(1/C) =+0.0044(± 0.0000)Quadrupole2-0.0792(±0.0121)T_2_O_2+0.1385(±0.0548)+chi4pathCluster -2.019andVolume log(1/C) =-0.0704(± 0.0398) logP-1.5501Ulcer score log(1/C) =+11.5236(±1.5660)chiV6chain+1.0933(±0.0853)chi3Cluster-0.0592(±0.0009) XcompDipole-2.8581andUlcer Score log(1/C) = + 0.0452(± 0.0615)XlogP-0.2637For 5-Methoxybenzimidazole series2. Acidity log(1/C) =-0.0469(± 0.0128)T_2_O_6+0.0391(± 0.0164)XcompDipole+0.0183(± 0.0110)DipoleMoment -1.3513andAcidity log(1/C) =-0.0315(± 0.0403)logP-1.6491Volume log(1/C) =+0.3554(± 0.0221)SaaNE-index-0.4466(± 0.1681)chi3Cluster+ 0.0439(± 0.0139)XcompDipole-2.3894andVolume log(1/C) = -0.0909(± 0.0778)logP-1.4993Ulcer score log(1/C) =-0.0067(±0.0000)Quadrupole2-9.6483(± 1.8345)chiV6chain-0.1924(± 0.0029)T_O_S_3+0.4548andUlcer Score log(1/C) = +0.1239(± 0.0906)logP-0.2800161

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