10.07.2015 Views

Download (4Mb) - Etheses - Saurashtra University

Download (4Mb) - Etheses - Saurashtra University

Download (4Mb) - Etheses - Saurashtra University

SHOW MORE
SHOW LESS

You also want an ePaper? Increase the reach of your titles

YUMPU automatically turns print PDFs into web optimized ePapers that Google loves.

Part-IIIAdvances Dihydropyridines and …OOROONHNHH 3 C CH 3NNHHFH 3 C NHCH 391R = 2-OCH 3 , 3-OCH 3 , 4-Cl, 2-Cl, 2-CH 3 , 4-CH 3 , 4-F, 4Cl etcH 3 C NHCH 393ROOF 3 C NNCF 3HHH 3 C NHCH 392R = 2-Cl, 3-Cl, 4-Cl, 2-NO 2 , 3-NO 2 , 4-CH 3 , 3Br, 4-OH etc.Figure-17. Structure of 91, 92 and 93 series DHPsThe structures of the DHPs reported from our research group were proved by X-raycrystallographic studies. 117-119 Some of similar DHPs were also found very potent againstM. tuberculosis. 120,121New C-4 fused heterocyclic systems in DHPs, AHC-52 94 (methyl 2-(N-benzyl-N-methylamino)ethyl-2,6-dimethyl-4-(2-isopropyl-pyrazolo[1,5-a]pyridine-3-yl)-1,4-dihydropyridine-3,5-dicarboxylate) and its pyridine analog AHC-93 95 has also beenreported to reverse MDR by inhibiting Pgp. 122-124423

Hooray! Your file is uploaded and ready to be published.

Saved successfully!

Ooh no, something went wrong!