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Part-IIImpact of Microwave…assisted fluorous synthesis protocol. Because of the favorable solution-phase reactionsand the simple F-SPE for intermediate purifications, this protocol is expected to be easilyadopted for the production of larger libraries.R 2ONC 8 F 17OOSR 1OR 1OR 2 R 5R 5 SHNSSR 3Pd(pddf)Cl 2 K 2 CO 3 ,MWI, 150 o C, 20 minR 4 B(OH) 240R 1R 2NSSOR 3R 3R 441OR 2NR 1OR 5 SHR 2R 5Pd(pddf)Cl 2 , K 2 CO 3 SNMWI, 150 o C, 20 min42R 1OSSO OR 1R 2NSOSR 443A new highly efficient microwave-assisted combinatorial synthesis for generatingcombinatorial libraries has been described by Cotterill et al. 44 The technology wasapplied to the high throughput, automated, one-step, parallel synthesis of diversesubstituted pyridines 44 and 45 (108 derivatives) using the Hantzsch synthesis. Theadvantages of microwave-assisted chemistry for combinatorial synthesis included a broadrange of available chemistries, simple reaction setup and product recovery readilyamenable to automation, extremely short reaction times, and high product yields.293