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2.3.2.2 Condensed pyrimidine libraries through MWIPart-IIImpact of Microwave…Huang et al., 57 have reported an expeditious and efficient method to prepare 2,6,9-substituted purines 64 in a two-pot reaction using microwave assisted reactions. The 2-chloro-6,9-substituted purines were prepared via a one-pot two-step reaction, whichinvolves a sequential S N Ar displacement of the C 6 chlorosubstituent with various anilinesand amines, followed by N-alkylation and N-arylation at the N 9 position with differentorganic halides and boronic acids.ClNR 1 R 2NNN1. Aniline/amine(R 1 R 2 NH),AcOH, MWI, 10 minNNAniline/amine (R 4 R 5 NH)NNClNNH2. Halide/bronic acid, (R 3 X)K 2 CO 3 , DMF, MWI10 minClR 1 R 2 R 3NNNaBF 4 , DMSO,MWI, 5 minNNNR 4 R 5 R 3A high-speed, one-pot combinatorial method for synthesizing diverse sets of imidazo[1,2-a]quinolines, pyrimido[1,2-a]quinolines 65 and quinolino[1,2-a]quinazolines 66 fromreadily available starting materials (12 analogues) has been reported. 5864NCCNORCHO+R 1R 2 HN R 1Ethylene glycolMWI, 120 o C, 4-8 minR 1 R 1 O RNCNNHR 3n O65R = Ph, 4-NO 2 Ph, 4-FPh, 4-BrPh, 4-CH 3 Ph etcR 1 = CH 3 , HR 2 = CH 2 COOH, CH 3 CHCOOHR 3 = H, CH 3n = 0,1O ROCNRCHONCCN+HNEthylene glycolMWI, 120 o C, 4-8 minNNHHOOCOR 1 66R 1R = Ph, 4-NO 2 Ph, 4-FPh, 4-BrPh, 4-CH 3 Ph etc302