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Part-IIAim of the Present WorkONHR 2ONNHS11H 2 NNRR 1OS12NOONNHR 1NnR 3HOR 1S13NOHONNRS14NR 2ONR 4SR 4 = H, Ac;R 1 ,R 2 = CH 3 , (-CH 2 -)n, n = 1, 2;15NH 2NONSR = H, Me, EtR 1 = alkyl, alkoxyl, OHN16NRSNSR = CH 3 , CH 2 Ph17OR 3NRR 1NR 2NSR = Me, Et, Ph, SMe18SNSR = CH 2 ; R 1 = PhCH 2 ;R 2 = H; R 3 = HR 1 , R 2 = piperidine, morpholine,N-methyl piperazine.19Recently, a series of 4-arylthieno[3,2-d]pyrimidines was reported as potent adenosine A 2Areceptor antagonist. These novel compounds showed high degrees of selectivity againstthe human A 1 , A 2B and A 3 receptor sub-types. Compounds 20 showed promising activityin vivo, suggesting potential utility in the treatment of Parkinson’s disease. 26OSSNN20NH 2312