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PrefaceThis entire cascade of reaction is initiated at the basic ‘N’ atom of the basic pyridine ringof the PMSB. 8In the present work, the basic pyridine ring of these compounds has been replaced withless basic pyrimidine ring, so the binding of these types of compounds is not so strong asPMSB and the target compounds can hopefully be even potential reversible PPI’s.Thus, a series of condensed pyrimidylmethylsulfinylbenzimidazoles 1 have beensynthesized through the reaction of appropriate condensed 2-chloromethylpyrimidin-4(3H)-one and 2-mercaptobenzimidazoles followed by the selective mild S-oxidation ofthe thioether linkage of the intermediates.ONHONSNHNY1In all 35 new target compounds have been synthesized and evaluated for antiulcer activityby the Shay’s rat pylorus ligation model 9 and results compared with omeprazole as thestandard, mainly keeping in mind and different observations or biological effects viz. pHof the gastric juice secreted, secreted acidity of the gastric juice secreted, volume ofgastric secretion and ulcer score. Some of the compounds have exhibited anti-acidsecretory and antiulcer activities comparable to the standard drug, omeprazole.A meaningful QSAR has been worked out to determine the optimal physico-chemicalcharacteristics and properties as well as the structural feature of these molecules, forachieving optimal activity.Part-II of this work deals with “The Novel Microwave Assisted Green ChemicalSynthesis of Condensed 2-Substitutedpyrimidin-4(3H)-ones Under SolventfreeConditions, their MWI Assisted Facile and Rapid Chlorination and their MultidrugReverting Activity”.xiv