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Discussion:Part-IResults and DiscussionFrom these results it is can be seen that multiple regression analysis method allowsbuilding statistically significant model. It is evident from all the six equations (models)developed. It is the electronic and stearic parameters that govern the activity of the protonpump inhibitors used in the present study.For 5-H-benzimidazole series of compounds, total acidity and volume of gastricsecretion is directly influenced by the two common electronic and steric parameters i.e.quadrupole2 and chi4pathCluster. This suggests that substitutions that increase thecontribution of quadrupole2 and chi4pathCluster may lead to increase in the activity. Fortotal acidity, the third descriptor, T_C_O_2 is inversely proportional to the activity thatmeans substitution with oxygen atom separated from any carbon atom (single or doublebonded) by two bond distance in a molecule may lead to negative effect on the activity.Similarly, for volume of gastric secretion, descriptor T_2_O_2 is inversely proportionalto the activity that means, substitution with oxygen atom separated from any doublebonded atom by two bond distances in a molecule may lead to negative effect on theactivity. For ulcer score, steric parameter (chiV6chain and chi3cluster) directly influencesthe activity, while the electronic parameter XcompDipole, is influencing the activity,inversely as indicated by its minus sign.In 5-methoxybenzimidazole series, descriptor XcompDipole (electronic parameter) isdirectly influencing the total acidity and volume of the gastric secretion. This suggeststhat substitution that leads to positive contribution in XcompDipole, may lead to increasein activity.For total acidity, dipole moment is contributing positively in the activity of the moleculewhile descriptor T_2_O_6 that is substitution on oxygen atom separated from any doublebonded atom by six bond distance shall lead to negative effect on the activity.For volume of gastric secretion, SaaNE-index (any nitrogen atom connected with twoaromatic bonds) plays important role in activity as it directly influences the activity.While increases in the value of chi3Cluster leads to negative effects on the activity. Forulcer score, both electronic (Quadrupole2) and stearic (chiV6chain) parameters influencethe activity in the indirect manner, that means substitutions that increases thecontributions of these parameters may lead to decrease in the activity. The thirddescriptor, T_O_S_3 that is presence of substitution on sulfur atom separated from anyoxygen atom (single or double bonded) by three bond distance may lead to decrease inthe activity.160