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Part-IISynthesis of PyrimidinesOOCH 3ONHOCH 3N+NH 2O CH 3dry HClSNOSO9j 13Similarly, Eid Fathy et al., 50 have synthesized novel naphtha[2,1-b]pyrano[2,3-d]-pyrimidin-4-one derivatives from the corresponding o-amino ester 14 under the influenceof dry HCl gas.OORCNOOOdry HClNH14ONH 2ONA.a Some Interesting Observations: Condensed 4-OxopyrimidinesThe condensation of thiophene o-aminoester 9b with ethyl cyanoacetate, when effected inthe presence of dry HCl gas yields the corresponding 2-carbethoxy-4-oxothienopyrimidine in 65% yields. 23,26 In contrast, the base catalyzed condensation,employing sodium ethoxide is reported to afford the 3-cyano-2,4-dihydroxythienopyridine31 15.OR 2CNCH 2 COOC 2 H 5R 1SN NHCH 2 COOC 2 H 5OR 1OC 2 H 5dry HClR 2NH 2S9bR 1 , R 2 = (-CH 2 -) 4R 1 = R 2 = CH 3CNCH 2 COOC 2 H 5NaOC 2 H 5R 2R 1S15HONCNOH239