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Part-IIIAdvances Dihydropyridines and …OHNNOHHO105OONNOOHO106Figure-24. Structure of 105 and 106 DHPsAdditional study on quantitative structure activity relationships of newly synthesized 1,4DHPs possessing a 1-pentyl group at the 4-position was carried out. 3-Pyridylpropylesterwas found to be one of the effective fragments for overcoming Pgp mediated MDR incultured human cancer cells, in vitro. It was found to increase the life span of micehaving Pgp over expressing MDR P388 leukemia. All 1,4-DHPs had weak calciumantagonistic activities, but there appeared no relationship between MDR reversing effectand calcium antagonistic activity. Some 1,4-DHPs such as 107 and 108 with weakcalcium antagonistic activities showed effective MDR reducing activities both in vitroand in vivo. In particular, compound 108 was expected to be the most suitable compoundto overcome MDR. 132430