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Part-1Review on Antiulcer LiteratureNNOYM 020 61Leach et al., 96 have reported H + /K + -ATPase inhibitory activity of 3-butyryl-4-[(2-methylphenyl)amino]-8-(2-hydroxyethoxy)quinoline, SK&F 97574 62. 68 It is found to bewell tolerated and efficacious in Phase-I studies.NHONOOHSK & F 97574 62Similar derivatives, 3-[3-(ethoxycarbonyl)propionyl]-8-methoxy-4-[(2-methylphenyl)amino]quinolines, (CP-113411) 63 have also been reported. Besides being reversibleinhibitors of gastric proton pump, they also inhibited bone absorption by osteoclasts. 97NHOOONOCP 133411 63Ife et al., 98 have reported the synthesis and evaluation of a series of 1-arylpyrrolo[3,2-c]-quinolines as inhibitors of H + /K + -ATPase. Unsaturation in the five membered ring of thisnucleus made little difference, but introduction of heteroatom in the same ring reducedthe activity drastically. Of the series, compound 64 showed reversible K + competitive35