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Part-IIAim of the Present Work21. Blaskienicz, P.; Verbraggent, H.; Kocj, H. Ger. Offen. 1979, 2411733, Chem.Abstr. 1979, 75, 140883.22. Arnaldo, C. Eur. Pat. 1985, 148436, Chem. Abstr. 1985, 103, 37491g.23. Monique, P.; Marylene, F. Eur. J. Med. Chem. 1988, 23, 453.24. Russo, F.; Santagati, M. Pharmaco Ed. Sci. 1983, 38, 762.25. Sauter, A.; Gerhard, S. Arch. Pharm. 1976, 101, 309.26. Gillespie, R. J.; Cliffe, I. A.; Dawson, C. E.; Dourish, C. T.; Gaur, S.; Giles, P.R.; Jordan, A. M.; Knight, A. R.; Lawrence, A. Lerpiniere, J. Misra, A.; Pratt, R.M.; Todd, R. S.; Upton, R.; Weissa, S. M.; Williamsonb, D. S. Bioorg. Med.Chem. Lett. 2008, 18, 2920.27. Munchhof, M. J.; Beebe, J. S.; Casavant, J. M.; Cooper, B. A.; Doty, J. L.;Higdon, R. C.; Hillerman, S. M.; Soderstrom, C. I.; Knauth, E. A.; Marx, M. A.;Rossi, A. M. K.; Sobolov, S. B.; Sun, J. Bioorg. Med. Chem. Lett. 2004, 14, 21.28. Wang, Y. D.; Johnson, S.; Powell, D.; McGinnis, J. P.; Mirandab, M.;Rabindranb, S. K. Bioorg. Med. Chem. Lett. 2005, 15, 3763.29. a. Bonnett, R. In The Chemistry of Carbon-Nitrogen Double bond, Ed. Patai, S.,Ed.; Interscience: New York, 1970; 597; b. Brown, D. J. The Chemistry ofHeterocyclic Compounds, vol. 16, An Interscience Publication: NewYork, 1962;pp 227-263, 306-347; c. Brown, D. J. The Chemistry of Heterocyclic Compounds,vol. 52, An Interscience Publication: New York, 1994; 241-278, 328-427, 439,551.; d. Brown, D. J. Compressive Heterocyclic Chemistry, vol. 3,. Katritzky, A.R., Ed.; part 2B, Pergamon press: Oxford, 1984; pp 57-156.30. Ferbering, A. G. Brit. Pat., 1929, 327, 450; Chem. Abstr. 241 5166, 1930.31. Cooper, F. C.; Partridge, M. W. J. Chem. Soc. 1954, 3429, i.d.b.i; 1955, 991.32. Wiessberger, A. In The Chemistry of Heterocyclic Compounds, vol. 1-21,Interscience, New York, 1950-1965.33. Elderfield, R. C. Ed., Heterocyclic compound, vol. 7, Wiley, New York, 1950-1961.34. Shaefer, F. C. In The Chemistry of Cyano Group, Ed. Rappoport, Z. Interscience:New York, 1970, 239.35. Johnson, F.; Madonero. In Advances in Heterocyclic Chemistry, vol-6, Kartrizky,A. R., Ed.; Academic Press: New York, 1966; pp 95-146.36. Dave, K. G.; Shishoo, C. J.; Devani, M. B.; Kalyanarman, R.; Ananthan, S.; Ullas,G. V.; Bhadti, V. S. J. Hetrerocycl. Chem. 1980, 17, 1497.319

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