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Summary and Conclusionconditions to afford variety of condensed pyrimidines, quinazolines, thienopyrimidines,furanopyrimidines, purines, pteridines, pyridopyrimidines, pyrrolopyrimidines,pyrazolopyrimidines, etc.Shishoo et al., have exploited the reactions of a variety of nitriles with a host of o-aminocarbonyl substrates, under the influence of dry HCl gas to obtain a wide range of 2-substituted-4-oxo/4-amino/4-chloro & 4-aryl condensedpyrimidines.Reactions that are adaptable for high speed and throughput syntheses have become animportant component of the modern medicinal chemist’s library, as a great number ofcompounds can be produced through such rapid parallel synthetic programs. Syntheticmethods that enable the rapid production of an array of heterocycles, useful for theidentification of new lead structures are of critical importance to the pharmacologicalactivity.Encouraging results in the MWI based syntheses of thiophene o-aminoesters involvingGewald reaction, as well as, thienopyrimidine bioisosteres of gefitinib under microwaveconditions gave an impetus to assess whether, these could be extended to the single potcyclocondensation of the nitriles with various o-aminoester substrates under solvent freeconditions using MWI. This was particularly of interest, especially for quickly generatingcompound libraries of increasing molecular diversity, through the development ofsynthetic methods that could combine the expediency of microwave energy.Thus, the aim of the this part was to use microwave irradiation for the synthesis ofcondensed 2-substitutedpyrimidin-4(3H)-ones involving the condensation of variety ofnitriles with o-aminoesters of thiophene, benzene, dimethoxybenzene and quinazolinonein the presence of catalytic amount of HCl alone or with the Lewis acid, AlCl 3 undersolvent free conditions for the first time. Further, it was decided to synthesize 4-chloroderivatives of these condensed 2-substituted pyrimidines-4-ones through MWI assistedfacile and rapid chlorination and also evaluated them for multi drug reverting activity onresistant cancer cell lines.In all 52 compounds has been synthesized in this part which were characterized byspectral data. The synthesized derivatives have been screened for their multi drug490