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Part-IExperimental21. Synthesis of 2-{[(5-methoxy-1H-benzimidazol-2-yl)sulfinyl]methyl}-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-one(IVxxi)2-{[(5-Methoxy-1H-benzimidazol-2-yl)thio]methyl}-3,5,6,7-tetrahydro-4H-cyclopenta-[4,5]thieno[2,3-d]pyrimidin-4-one (IIIxxi, 2.0 gm; 0.0054 mole) was dissolved in 125 mlmethanol and 100 ml methylene dichloride by stirring at room temprature. Thereafter, thereaction mixture was chilled in an ice salt bath while maintaining the temperature below0 o C. To this clear solution, methanolic solution of m-CPBA (1.16 gm; 0.0065 mole) wasadded while stirring and the reation was continued for 30-45 mins. After completion ofthe reaction, worked up was done as for the compound IVi.M.P. : 210-212 o C; Yield: 48%.Mol. formula : C 18 H 16 N 4 O 3 S 2 ; Mol. Wt. 400.4.IR (KBr) cm -1 : 3394(γ NH ), 2954(γ C-H ), 1659(γ CONH ), 1029(γ S-O ), 808(γ C-S ).22. Synthesis of 2-[(1H-benzimidazol-2-ylsulfinyl)methyl]-3,5,6,7,8,9-hexa-hydro-4Hcyclohepta[4,5]thieno[2,3-d]pyrimidin-4-one(IVxxii)2-[(1H-Benzimidazol-2-ylthio)methyl]-3,5,6,7,8,9-hexahydro-4H-cyclohepta[4,5]thieno-[2,3-d]pyrimidin-4-one (IIIxxii, 2.0 gm; 0.0054 mole) was dissolved in 125 ml methanoland 100 ml methylene dichloride by stirring at room temprature. Thereafter, the reactionmixture was chilled in an ice salt bath while maintaining the temperature below 0 o C. Tothis clear solution, methanolic solution of m-CPBA (1.16 gm; 0.0065 mole) was addedwhile stirring and the reation was continued for 30-45 mins. After completion of thereaction, worked up was done as for the compound IVi.M.P. : 196-199 o C; Yield: 37%.Mol. formula : C 19 H 18 N 4 O 2 S 2 ; Mol. Wt. 398.5IR (KBr) cm -1 : 3250(γ NH ), 2916(γ C-H ), 1651(γ CONH ), 1057(γ S-O ), 744(γ C-S ).NMR (DMSO-d 6 )δppm : 1.68-1.71 (6H, m, CH 2 at 6, 7, & 8), 1.88 (2H, t, CH 2 at 5, J =3.30), 3.30 (2H, t, CH 2 at 9, J = 5.32), 5.35 (2H, s, CH 2 at SCH 2 ),7.20-7.69 (4H, m, H at imidazole), 12.30 (1H, s, NH), 13.20 (1H,s, NH).212