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Download (4Mb) - Etheses - Saurashtra University

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Part-IIImpact of Microwave…synthesis (15 derivatives). Purification steps were minimized, analytical methods weresignificantly simplified, and a much defined products were yielded.R 2 HN SSHNR 2R 1NOOnONR 1OK 2 CO 3 , CH 2 Cl 2MWI, 120 W, 7 minOR 2SNOR 1N62R 1 = Isopropyl, n-butane, etcR 2 = 4-F Ph, 4-NO 2 Ph, 3-CH 3 Ph, 3-F Ph etcPorcheddu et al., 56 have described an efficient approach to synthesize the libraries (39compounds) of substituted pyrimidines 63 starting from different β-keto-esters or β-ketoamides,using a low cost and high loading polymer, under very mild conditions usingmicrowave irradiation.NNRNNHN+OOYDMF, CamphorsulfonicAcid (cat.)MWI, 80 o C,30 minROOYR 1NCH(OMe) 2R 1Y= O, NC 2 H 5R = CH 3 , C 2 H 5 , iPrH 2 NNH 2NR 3 R 2NNHRR 2NY R 1R 3NNO63R 1 = C 2 H 5R 2 ,R 3 = H, CH 3 , C 2 H 5 , H, Ph etc301

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