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R 1 R 2 R X Yield(%)Part-IISynthesis of PyrimidinesR. Solv. Reference-(CH 2 ) 4 - -NHC 6 H 4 Br-4 S 56.1 E-C 34-(CH 2 ) 4 - -SC 2 H 5 S 68 B-h 57-(CH 2 ) 4 - -SC 3 H 7 S 79 B-h 57-(CH 2 ) 4 - -SC 4 H 9 S 84 B 57-(CH 2 ) 4 - -SCH 2 C 6 H 5 S 70 B 57-CH 3 -CH 3 -SCH 3 S 66 I 29-CH 3 -CH 3 S 35 B-H 29N O-CH 3 -CH 3 -SC 3 H 7 S 83 I 57-CH 3 -CH 3 -SC 4 H 9 S 72 I 57-CH 3 -CH 3 -SCH 2 C 6 H 5 S 71 E-C 57-CH 2 CH 2 N(CH 2 C 6 H 5 )CH 2 - 3-C 6 H 4 N S 43 D-E 31-(CH 2 ) 5 - -SCH 2 C 6 H 5 S 56 E-C 57-C 6 H 5 -C 6 H 5 -CH 3 O 68 B 29-C 6 H 5 -C 6 H 5 -C 6 H 5 O 47 B-M 29-C 6 H 5 -C 6 H 5 -CHCl 2 O 55 B-H 29-C 6 H 5 -C 6 H 5 -CO 2 C 2 H 5 O 35 B-H 29-C 6 H 5 -C 6 H 5 -CH 3 -N(C 6 H 5 )- 45 E-D 39B=Benzene, H = Hexane, I = Isopropanol , C = Chloroform, E =Ethanol, M = Methanol, D =Dimethylformamide, Ch =Cyclohexane, EA =EthylacetateThe hydrogen chloride catalysis has also been extended to the synthesis of some novel 2-substituted 4-aminobenzo(b)furo[3,2-d]pyrimidines (Table 31) from the corresponding 3-amino-carbethoxybenzo(b)furan 12e. However, the yields of the products are below 50%.12eONH 2+ RCNCNdry HClIIIdONRNNH 2246