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Part-1Review on Antiulcer Literaturegastric H + /K + ATPase inhibitory activity of these compounds completely recovered tonon-treated group levels after washout, confirming the reversible inhibition of gastricH + /K + ATPase. 115 Another compound from the same series, 2-(2,3-dimethyl-1-propyl-1Hpyrrolo[3,2-c]pyridine-7-yl)-1,2,3,4-tetrahydroisoquinolinehydrochloride was also foundvery potent inhibitor of H + /K + ATPase with same mechanism of action. 116R 1 R 2NNR 484R 1 = H, alkyl, alkoxy, hydroxy, cycloalkyl, thiazolyl, alkenyl, benzyl etc.R 2 = H, alkylR 3 = H, alkyl, alkenyl, benzyl, etc.R 4 = 1,2,3,4-tetrahydroisozuinolinyl, benzyloxy, amino, alkylcarbonyl,phenoxycarbonyl, benzyl etc.R 3Another novel series of pyrrolo[2,3-c]pyridine derivatives 117 85, analogues to the aboveseries in structure was found to be very potent as reversible inhibitors of H + /K + ATPase,especially the compound, 7-(4-fluorobenzyloxy)-2,3-dimethyl-1-(prop-2-ynyl)-1Hpyrrolo[2,3-c]-pyridinehydrochloride which was very potent with ED 50 of 14.0 mg/kg.Another analogues series 118 , pyrrolo[3,2-b]pyridine has also been equally found verypotent. The compound, 7-(4-fluorobenzyloxy)-1-isobutyl-2,3-dimethyl-1H-pyrrolo[3,2-b]pyridine hydrochloride was very effective with ED 50 of 2.4 mg/kg.R 3 R 2R 4 85NNR 5R 1R 1 = H, alkyl, alkoxy, alkoxycarbonyl, alkylcarbonyl, alkylamine, naphthyl, quinolinyl,thiazolyl, thiophenyl, isoxazolyl, alkenyl, acetyl, phenyl etc.R 2 = alkylmstraight chain or branchedR 3 = H, alkyl, alkylsulfanyl, etc.R 4 = H, halogen, cyno, hydroxycarbonyl, alkoxycarbonylamino, morpholinocarbonyl etc.Prodrugs of benzimidazole-type proton pump inhibitors of general structure 86 have beenstudied, to develop agents that slowly hydrolyze to provide benzimidazole type protonpump inhibitors which inhibit exogenously or endogenousely gastric acid secretion along43