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Part-IIAim of the Present WorkAnother novel series of thienopyrimidines and thienopyridines have been identified aspotent inhibitors of VEGFR-2 kinase. Compound 21 was found most potent with IC 50values of 80 nM and 3 nM for VGFR and EGFR respectively. 27HNHNSNNVGFR IC 50 = 80 nMEGFR IC 50 = 3 nM21Interestingly, a series of novel thieno[2,3-d]pyrimidin-4(1H)-one based analogs werefound potent inhibitor of the growth of human colon tumors. Compound 22 was the mostpotent inhibitor of the tumor cell growth. 28OSNONHOO 223.3 Synthesis of Pyrimidines:The synthesis of condensed pyrimidines is a very important process which is subject toimprovement, routinely. The regularly employed synthetic methodology involvesannealation of the pyrimidine ring on an appropriately substituted heterocycles in which avariety of o-aminocarbonyl heterocycles have been cyclocondensed with a host ofreagents namely amides, thioamodes, imidates, amidines, etc., mostly under basicconditions to afford variety of condensed pyrimidines, quinazolines, thienopyrimidines,furanopyrimidines, purines, pteridines, pyridopyrimidines, pyrrolopyrimidines,pyrazolopyrimidines, etc., 29 (Scheme 1).313