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CH 3CH 3Part-IIIAdvances Dihydropyridines and …OCH 3CH 3OOONH 3 C NHCH 347NOCH 3OCH 3OOH 3 COONH 3 C N CH 3NCH 3n50OCF 3ON 3C 2 H 5 OOOHNH 3 C NHCH 3Azidopine 51OFigure-7. Structures of various DHPs known as MDR reversal agentsOver and above, these clinically established molecules, some other DHPs could alsohighlight themselves for their potent MDR reversal property.[3H]azidopine 51, a radioactive photoactive DHPs calcium channel blocker, photolabelsPgp in membrane vesicles from KBCl cells. This photolabeling was almost completelyinhibited by the excess DHPs analogues that reversed or lowered drug resistance. Incontrast, the labeling was not significantly inhibited by analogues that do not reverseresistance. Inferencing from this Kamiwatari et al., screened a series of DHPs analogues409