Fluids Hypertension Syndromes: Migraines, Headaches, Normal ...

Fluids Hypertension Syndromes – Dr. Leonardo Izecksohn – page 121
There is a cyclic worsening of migraines with the menstrual periodicity.
The Menstrual Migraine is secondary to the cyclic fluids accumulation and discharge determined by
the rise and downs of the hormone Estrogen, causing the intraocular, Cerebrospinal and inner ears fluids’
pressures raises and downs. It is denominated as “Premenstrual Syndrome” or Premenstrual dysphoric
disorder.
The raising and downs timings of the Cerebrospinal and Ocular fluids’ pressures are different one
from the other. Each time one of these pressures is above or below the other, the Lamina Cribosa of the
Optic Nerve is stretched from one side to the other, and it aches as Migraines and all the other signs
and symptoms. The same mechanism causes the aches at other nerve’s lamina cribosa or foramen.
After expelling the excessive fluids, all the pressures and stretches reduce and the Migraine finishes.
We observed increased monthly cyclic migraines in women who do not menstruate, consequent of
surgeries or medications, but we did not made statistics about this.
“As many as 60% of women migraineurs report an association between migraine and menstruation,
and evidence suggests that estrogen withdrawal may be a trigger for menstrual migraine in susceptible
women. Moreover, in the majority of women, migraine frequency increases during the pill-free interval
with oral contraceptive use and during the postpartum period, which are other times of decreasing estrogen
levels. Migraine frequency tends to decrease during periods of increasing or stable estrogen
levels”. (Zacur HA).
“Esterified estrogens combined with methyltestosterone produce a clinically significant increase in
Intra-Ocular Pressure in postmenopausal women with dry eye syndrome.” (Khurana RN, Labree LD,
Scott G, Smith RE, Yiu SC).
“Headache, especially migraine, was more likely among premenopausal women using oral contraceptives
containing estrogen.”(Aegidius K, and others).
As Menstrual Migraines are simultaneously symptoms (Migraines) and etiologies (menses), their statistics
are above, at the item “All Migraines” (item VI).
As the estrogen cycle only occurs in women on the fertile period or when taking contraceptives, this
etiology added with all the others cause to them much more migraines and with bigger intensity than to
other women.
We conclude that Premenstrual Migraines have high correlation with Cerebrospinal Fluid Hypertension
syndrome, and low correlation with Ocular Hypertension Syndrome and Glaucoma.
XI- 13) - Medications (without caffeine) that raise the fluids pressures:
There are many medications already known as raising the intraocular pressure and aggravating the
glaucoma, as corticosteroids, psychotropics, vasodilators and other steroids. We suppose that these
medications also raise other fluids pressures, as the Cerebrospinal fluid and the inner ears’ Perilymph
and Endolymph. We did not made statistics detailing which medication the patients were using.
“NSAIDs can activate the renin-angiotensin-aldosterone cascade, and the increased Aldosterone leads
to Na + -retention and overhydration”(Poul-Erik Paulev) 12 .
Angle closure glaucoma was associated with uveal effusion on therapy with topiramate use. (Thambi
L, Kapcala LP, Chambers W, et al).
We had 102 patients who mentioned regular use these medications. They were 70 women and 32
men, with average age of 47 years.
These 102 patients’ users of medications that raise the fluids’ pressures complained about:
- 43 patients (42.2%) wide frontal migraines;
- 40 patients (39.2%) worsened their aches at morning;
- 31 patients (30.4%) with tearfulness and Rhinitis with coryza (rhinorrhea);
- 29 patients (28.4%) with eye’s itching or blepharitis;
- 22 patients (21.6%) with occipital migraines;
- 21 patients (20.6%) with ocular aches;
- 21 patients (20.6%) with temporal or head-top (vertex) migraines;
- 20 patients (19.6%) with eyes redness;