Fluids Hypertension Syndromes: Migraines, Headaches, Normal ...

Fluids Hypertension Syndromes – Dr. Leonardo Izecksohn – page 243
XVI - 81) Epinephrine increase: On “47 healthy, nonsmoking, habitual coffee drinkers...Caffeine administration
significantly raised average ambulatory blood pressure during the workday and evening by
4/3 mm Hg and reduced average heart rate by 2 bpm. Caffeine also increased by 32% the levels of free
epinephrine excreted during the workday and the evening. In addition, caffeine amplified the increases
in blood pressure and heart rate associated with higher levels of self-reported stress during the activities
of the day. Effects were undiminished through the evening until bedtime.”. (Lane J D, and others).
XVI - 82) Erysipelas: These bacterial infections are facilitated by the lymphatic edemas. As caffeine,
wine and beer cause lymphatic edemas, they also facilitate the occurrence of erysipelas.
XVI - 83) Esophageal and stomach cancer: “Mononitrosocaffeidine and dinitrosocaffeidine are new
N-nitroso compounds obtained from in vitro nitrosation of caffeidine, a hydrolysis product of caffeine
present in a typically made and widely consumed tea from Kashmir (India), a high incidence area of
esophageal and stomach cancer. In BD-IX rats... All three dose groups of Mononitrosocaffeidine
treated rats showed localization of tumours in nasal cavity (93.9-100% of all malignant tumours). The
tumours were histologically diagnosed as neuroepitheliomas of the olfactory epithelium (neuroblastoma
of the bulbus olfactorii) and squamous cell carcinoma of the nasal cavity in the ratio of 3:1.
No tumours of the nasal cavity were observed in the untreated controls. Dinitrosocaffeidine, in contrast,
induced squamous cell carcinoma of forestomach in 100% animals at low and high doses, of
which nearly half the tumours metastasized predominantly into the peritoneum. No forestomach tumours
were seen in the untreated controls. The data presented here clearly show the potential for induction
of malignant tumours and distinct organ-specificity by Mononitrosocaffeidine and dinitrosocaffeidine
in rats, and support the postulate that a chronic exposure to these compounds may provide a
carcinogenic risk for high incidence of gastrointestinal cancers in Kashmir.” (Ivankovic S, and others).
XVI - 84) Essential Tremor, Muscle twitchin and caffeine intoxication: “Our data indicate that endogenous
adenosine mechanisms are active in tremor, thus supporting the clinical notion that caffeine,
a nonselective adenosine receptor antagonist, can trigger or exacerbate essential tremor.” (Bekar L,
and others).
XVI - 85) Excitement: It is caused by the caffeine intoxication, mainly in children.
XVI - 86) Fear and anxiety increases: “Oral Caffeine (240-720 mg) had anxiogenic properties.”
(Uhde T W, and others).
XVI - 87) Fertility reduced. Lower fecundability. Infertility:
“104 healthy women who had been attempting to become pregnant for three months were interviewed...
Women who consumed more than the equivalent of one cup of coffee per day were half as
likely to become pregnant, per cycle, as women who drank less. A dose-response effect was present…
When the data were treated by the life table approach, 6% of the women were still not pregnant in the
low consumption group by cycle 13, compared to 28% in the high consumption group, a relative risk of
4.7. The mechanism of action of caffeine on fecundability is unknown.” (Wilcox A, and others).
“Fecundability has been defined as the ability to achieve a recognized pregnancy...Couples who were
20 to 35 years old, lived with a partner, and had no previous reproductive experience... In all, 1596
cycles and 423 couples were included in the analyses... Nonsmoking women who consumed 300 to 700
mg/d caffeine had a fecundability odds-ratio of 0.88, whereas women with a higher caffeine intake had
a fecundability odds-ratio = 0.63... No dose-response relationship was found among smokers. Among
males, the same decline in point estimates of the fecundability odds-ratio was present. Smoking women
whose only source of caffeine was coffee (>300 mg/d) had a reduced fecundability odds-ratio = 0.34...
An interaction between caffeine and smoking is biologically plausible, and the lack of effect among
smokers may be due to faster metabolism of caffeine... Nonsmoking women who wish to achieve a
pregnancy might benefit from a reduced caffeine intake.” (Jensen T K, and others).