Fluids Hypertension Syndromes: Migraines, Headaches, Normal ...

Brazil, by drinking cachaça with “Red Bull”.
Fluids Hypertension Syndromes – Dr. Leonardo Izecksohn – page 280
XVI - 248) Withdrawal symptoms:
“A literature search identified 57 experimental and 9 survey studies on caffeine withdrawal that met
inclusion criteria. The following 10 symptom fulfilled validity criteria: headache, fatigue, decreased
energy/activeness, decreased alertness, drowsiness, decreased contentedness, depressed mood,
difficulty concentrating, irritability, and foggy/not clearheaded. In addition, flu-like symptoms,
nausea/vomiting, and muscle pain/stiffness were judged likely to represent valid symptom categories.
In experimental studies, the incidence of headache was 50% and the incidence of clinically significant
distress or functional impairment was 13%. Typically, onset of symptoms occurred 12-24 h
after abstinence, with peak intensity at 20-51 h, and for a duration of 2-9 days. In general, the incidence
or severity of symptoms increased with increases in daily dose; abstinence from doses as low as 100
mg/day produced symptoms… Expectancies are not a prime determinant of caffeine withdrawal and
avoidance of withdrawal symptoms plays a central role in habitual caffeine consumption.” (Juliano L
M, and Griffiths R R).
“Cessation of daily caffeine consumption significantly increased the mean velocity, systolic velocity
and diastolic velocity in all four cerebral arteries. In the middle cerebral artery, the pulsatility
index was significantly decreased…significantly increased the EEG theta power…also increases in
heavy feelings in arms and legs and decreases in ability to concentrate.” (Jones H E, and others).
Note: These above sicknesses are caused by caffeine together with its metabolites. The metabolites
are produced in our body mainly by the Cytochrome P450 1A2, in order to detoxify the caffeine. The
main metabolites of the caffeine are:
Paraxanthine – 80%;
Theobromine – 12%;
Theophylline – 4%;
1,3,7-Trimethyluric acid – 1%. (Regal K A, and others)
We conclude that Caffeine is poisonous, treacherous and a scattered health worsening factor.
The caffeine protracted use acts at least by 19 pathological ways:
1) Caffeine's effects on health are different when in few minutes, in few hours or after months. The
same occurs with theobromine (chocolate).
2) The personal sensibility to caffeine is varied: In each patient the doses and effects are different.
The main origin of this personal sensibility is inheritance, but it also can be acquired. Some resistant
patients becomes sensible to caffeine with age. Smoking protects the person from some effects of caffeine.
Some people are entirely intolerant to caffeine, and to them, even one little cup of coffee or a
small chocolate is poisonous and cause them to be sick. The asseveration that "to drink until 300 mg of
caffeine per day is safe to any people” is a gross error.
3) Caffeine is treacherous: caffeine alone, or with analgesics, reduce the migraines and headaches in
minutes, but after few hours or at the next day, caffeine is the main etiology to all the migraines and
variants. Caffeine doubles the total number of patients suffering, and it increases all their migraines,
signs and symptoms.
4) Caffeine is a generic aches intensifier everywhere in the body, after months of daily use.
5) Caffeine causes edemas. After months of daily use, Caffeine retains water in the body, it increases
the fluids’ retention caused by other etiologies or risk factors, which results on the Fluids Hypertension
Syndromes and small spread edemas. Caffeine daily drinks can increase the body weight up to 4 kilograms
(8.8 pounds) only with retained water.
6) Caffeine alone is the etiology of more than 200 sicknesses, but together with other etiologies, caffeine
is a worsening factor of more than 400 signs, symptoms and sicknesses above mentioned at the
Summary.
7) Caffeine and its metabolites are carcinogenic. When already there are cancer cells, caffeine is also
toxic to them and stimulates its dying, without entirely curing the cancer. So, caffeine is also a chemical
therapy to cancer.