Fluids Hypertension Syndromes: Migraines, Headaches, Normal ...

A(1)/A(2A) receptors.” (Nobrega J N, and others).
Fluids Hypertension Syndromes – Dr. Leonardo Izecksohn – page 241
XVI - 75) Edemas: In Legs, Belly, Buttocks, Bosom, Arms, Hands. We found in our patients drinkers
of caffeine and excessive water that it is common to have 0.5 to 2 kilograms (1 to 4 pounds) of
water retention spread all over the body. Those patients over 90 kilograms of weight can retain until 4
kilograms of water. It resembles obesity, but it is not fat: it is edema, only water or inter-cellular fluids.
This water retention increases the belly, buttocks, bosom, arms, hands, and the weight; it is cold and
it does not ache, and usually it causes leg’s edema and varicose veins. A patient we had even could not
close her swollen hands.
We have the impression that along the years, these chronic caffeinated edemas are replaced by fat tissue,
but we are not sure about this.
This water retention caused by the caffeine plus water is remarkable, but does not reach the big dimension
obtained by the beer drinkers. Stopping the caffeine and the excessive water drinks, in one
month the patient loses the excessive half to two liters of water retained, loses weight, reduces the
belly, legs and all edemas, lightens and becomes healthier. It is not necessary any medication. All patients
enjoy it. Here is one patient:
Curing many sicknesses, caused by caffeine and excessive water, at a same time: We had a 78year-old
woman, white, housewife, two children. She was 1.67 meters tall (5 feet and 6 inches), weighing
73 kilograms (161 pounds). For many years, she drank daily 5,500 milliliter of water and much
coffee. She complained of eyes sores, eyes redness, tearfulness, eyes itching, arterial hypertension, and
her both legs presented knees aches, rheumatism, multiple big varicosities and edema. On ophthalmological
exam, we found intraocular pressures of 20 and 20 mmHg, which are moderately high, Optic
Nerves’ disks cups with 0.5/3/0/0 in both eyes and deep anterior chambers, which are physiologic. She
was taking eight different medications daily, without success. We substituted all her medications by
only Timolol Maleate 0.5% eye drops twice daily, restriction of her water drank and elimination of all
caffeine.
After two months she returned all better, weighting only 71 kilograms (156 pounds) without any diet
or medication, walking better, without any ache, smaller varicosities and near absent legs' edemas.
Her intraocular pressures show 18 and 16 mmHg right and left eyes, which is better than before.
This is an example of the signs and symptoms caused by the Ocular Hypertension Syndrome without
glaucoma, and simultaneous many other diseases, all caused or worsened by the excessive drinks of
water and caffeine. Stopping the vicious drinks, it is easy to cure all this, isn't it?
XVI - 76) Embryos malformations (birth defects): “Caffeine or theophylline alone (2.5-5.0
mg/egg) retarded growth in a dose-dependent fashion. Doses of 5.0 mg caffeine and theophylline produced
beak malformations in 4.9% and 57.1% of embryos, respectively. Structural defects following
co-administration of methylxanthines and beta-adrenomimetics were frequently observed in limbs
(primarily lower limbs with predilection for left-sided oligodactyly) and beak... limb hematomas, hygromas
in the nuchal region, and prominent generalized edema... concomitant administration of 2.5 mg
caffeine and 1 microgram isoproterenol... produced at least one of the embryopathies listed above in
87.9% of treated embryos and frequently induced beak (24.2%) and lower limb defects (75.8%) in addition
to nuchal hygromas (9.1%). Similar severe malformations were observed following administration
of 3.8 mg theophylline with 1 microgram epinephrine. Embryos that died within 12-48 hours following
drug insult demonstrated marked cardiac dilation, apparently due to congestive heart failure.”
(Bruyere H J, and others).
“Caffeine was administered intraperitoneally to CD-1 mice on days 11 and 12 of pregnancy at doses
of 80-250 mg/kg. A dose-related pattern of malformations was seen that included mainly cleft palate,
limb malformations, and hematomas. Many of the limb malformations were examined in preparations
stained for cartilage and bone and a number of unique structural arrangements were found. As in previous
studies, an asymmetric response was seen, the left limbs being affected more often than the right.
Transplacental passage of caffeine was also studied. Caffeine and many metabolites pass into the embryo
and attain concentrations slightly below those in maternal plasma.” (Scott W J Jr).