Fluids Hypertension Syndromes: Migraines, Headaches, Normal ...

Fluids Hypertension Syndromes – Dr. Leonardo Izecksohn – page 274
XVI - 211) Sperm damage: On sperm analyses, “men (healthy non-clinical group of 80 non-smokers
(mean age: 46.4 years, range: 22-80 years) with no known fertility problems), who consumed >3 cups
coffee per day had approximately 20% higher percentage tail DNA …damage associated with doublestrand
DNA breaks.” (Schmid T E, and others).
“Among 2,554 young Danish men recruited when they were examined to determine their fitness for
military service in 2001-2005...High cola (>14 0.5-L bottles/week) and/or caffeine (>800 mg/day) intake
was associated with reduced sperm concentration and total sperm count, although only significant
for cola.” (Jensen T K, and others).
XVI - 212) Snoring excessively: Our obese patients who present excessive snoring when sleep, became
better withdrawing their caffeine drinks. The most serious cases were the patients with Obstructive
Sleep Apnea Syndrome, described above.
On Montreal, Quebec, Canada...“Regular snoring was significantly associated with male sex, age 25
or more, obesity, daytime sleepiness or naps, night time awakenings, consuming large amounts of caffeine,
and smoking.” (Ohayon M M, and others).
XVI - 213) Stress worsening: “Caffeine elevated urinary epinephrine levels during work by 37% but
did not affect norepinephrine or cortisol levels… Results suggest caffeine may increase the activity of
the sympathetic adrenal-medullary system during everyday activities in the work environment. This action
may potentiate psychophysiological responses elicited by occupational stressors.” (Lane J D).
“High doses of caffeine produce a stresslike neuroendocrine response in rats. This response is characterized
by increased serum corticosterone, beta-endorphin, and decreased serum growth hormone and
TSH. A person must consume 500 mg caffeine (equivalent to 5 cups of coffee) in one sitting for there
to be any possible endocrine effects.” (Spindel E).
XVI - 214) Stroke: On “390 subjects (209 men, 181 women) … after acute ischemic stroke... The relative
risk (RR) of stroke in the hour after consuming coffee was 2.0. There was no apparent increase in
risk in the hour following consumption of caffeinated tea (RR = 0.9) or cola (RR = 1.0). The association
between ischemic stroke in the hour after coffee consumption was only apparent among those
consuming ≤1 cup per day but not for patients who consumed coffee more regularly. Coffee consumption
transiently increases the risk of ischemic stroke onset, particularly among infrequent drinkers.”
(Mostofsky E, and others).
“Overall, the impact of dietary caffeine on population blood pressure levels is likely to be modest,
probably in the region of 4/2 mmHg. At these levels, however, population studies of blood pressure indicate
that caffeine use could account for premature deaths in the region of 14% for coronary heart disease
and 20% for stroke.” (James J E).
When caffeine is taken together with ephedra or synephrine, it can cause brain stroke:
“Following the 2004 ban of ephedra, which was linked to several cases of stroke and myocardial infarction,...
synephrine is touted by its promoters as a "safe" alternative to ephedra and is often combined
with caffeine, as in the supplement Xenadrine-EFX. We report a case of left middle cerebral
artery vasospasm and stroke in a young healthy patient in the setting of Xenadrine-EFX use.” (Holmes
R O Jr, and Tavee J).
XVI - 215) Stuttering: Stuttering is related with anxiety disorders: On “92 adults seeking treatment for
stuttering... the stuttering group had six- to seven-fold increased odds of meeting a 12-month diagnosis
of any DSM-IV or ICD-10 anxiety disorder. In terms of 12-month prevalence, they also had 16- to 34fold
increased odds of meeting criteria for DSM-IV or ICD-10 social phobia, four-fold increased odds
of meeting criteria for DSM-IV generalized anxiety disorder, and six-fold increased odds of meeting
criteria for ICD-10 panic disorder. Overall, stuttering appears to be associated with a dramatically
heightened risk of a range of anxiety disorders.” (Iverach L, and others).
As caffeine is one etiology of anxiety disorders, caffeine must be also a risk factor for stuttering. It is
only missing a study to prove this.