Fluids Hypertension Syndromes: Migraines, Headaches, Normal ...

Fluids Hypertension Syndromes – Dr. Leonardo Izecksohn – page 153
The headache occurred between 1.5 h and 5.5 h after infusion and was unilateral in 18/20 (90%) responders.
During migraine, blood vessel diameters were no different from baseline, nor between headache
and non-headache sides.” (Schoonman G G, and others).
“In migraine attacks with half-sided headache, there was only dilatation on the headache side of
Middle meningeal artery of 12.49% and of Middle cerebral artery of 12.88% and no dilatation on the
nonheadache side of Middle meningeal artery and Middle cerebral artery. In double-sided headache we
found bilateral vasodilation of both Middle meningeal artery and Middle cerebral artery.” (Asghar M S
and others).
Calcitonin gene related peptide (CGRP) causes vasodilation and migraines: “Release of Calcitonin
gene related peptide in the dorsal spinal cord has been associated to nociceptive transmission,
and release from peri-vascular nerve endings causes neurogenic vasodilation. Calcitonin gene related
peptide levels increase in the cranial circulation during migraine attacks, and Calcitonin gene related
peptide injection in migraineurs results in migraine-like attacks.” (Benemei S, and others). Calcitonin
gene related peptide antagonists cause inhibition of this vasodilation and can prevent or terminate some
migraines.
The vasodilation causing headaches explains the quickly headaches improvement caused by vasoconstrictor
medications as Ergots and Triptans, without curing their etiologies. Their overuse cause
brain ischemia with headaches. Their withdrawal cause vasodilation and headaches.
XII d) Substance “P” and caffeine. There is a coincidence about Substance P and caffeine: Besides
being a potent vasodilator dependent of nitric oxide release, many doctors related Substance P with
some inflammatory processes in the joints, pain in arthritis, back pain, fibromyalgia, eczema, vomits
and headaches. Coincidentally, all these disturbs are also related with caffeine. Maybe this is the explanation:
“The messenger ribonucleic acid for ... Substance P, is elevated in the striatum (a subcortical
part of the cerebrum) by high doses of caffeine (Svenningsson et al., 1997. Cited by Fredholm B B,
and others).
XII e) Excessive water drinks cause acute fluids’ exudation: The water drink test, 1000 milliliters
(two pints) of water drank in 5 to 15 minutes, which raises the intraocular pressure after 15 to 60
minutes, is the evidence of this pathophysiology. This acute water drink causes fluids exudation in all
over the body, not only in the eyes. It increases the serum transudation through the arterial capillaries
in all over the body. In the eyes, brain, and inner ears, this acute fluids exudation is simultaneously etiology
and trigger of the three Fluids Hypertension Syndromes.
XII f) Sleeping causes 3 distinct etiologies to the fluids' hypertension:
1- Laying flat on the bed causes water overload in the head. The supine intraocular hypertension:
Laying flat on the bed, known as the supine position, causes the spread to all the body of the water
previously retained by gravity in the legs, pelvis and belly during the day. This water is daily retained
in the veins, in the lymphatics and mainly in the interstitial space. It is a small spread edema, without
clinical symptoms.