Fluids Hypertension Syndromes: Migraines, Headaches, Normal ...

Fluids Hypertension Syndromes – Dr. Leonardo Izecksohn – page 251
- Irritable Bowel Syndrome, Migraines, Cerebrospinal and Ocular Hypertension caused by caffeine:
We had a 40-year-old Mulatta, laboratory technician, no child. She was 1.62 meters (5 feet and
4 inches) tall, 55 kilograms (121 pounds) of weight. She was suffering from strong Migraines for the
last 25 years, worsening with menses. From 3 years until now, she was suffering with wakening headaches
on her frontal and occipital areas. She suffered also with photophobia so intense that she needed
to use dark glasses during all the day, until inside her working room. Some nights she wakes at 3:00
o’clock at morning suffering with intense headaches. She also suffered all those years of excessive
tears, nausea and retching, buzzing, eyelids edemas at morning and eyes redness. She was suffering
from years of Irritable Bowel Syndrome (Colitis), already examined and medicated without any success.
She used to drink daily coffee 200 milliliters (7 fluid ounces), Guaraná 300 milliliters (10 fluid
ounces), and colas 600 milliliters (20 fluid ounces). For medicate her headaches, she used caffeinated
analgesics. Once 2 years ago, she suffered a spontaneous sub-conjunctival hemorrhage at her right
eye. On the ophthalmological exam, we found no need of eyeglasses, and intraocular pressures of 24
mmHg on both eyes, which is an intraocular high-tension. Her both Anterior chambers were deep,
physiologic. Her both Optic Nerves’ disks on direct ophthalmoscopy show 0.5/1/0/0.5 (cup diameter/
cup depth/ Lamina Cribosa’s pores visibility/ borders edema), which is the sign of the Cerebrospinal
Fluid Hypertension. We prescribed her to stop all caffeine, as in beverages, as in medications. We also
prescribed her eye drops of Timolol Maleate 0.5% twice daily, in order to lower her intraocular pressures.
After one month, she returned telling us that she suffered 10 days of intense headaches caused by the
caffeine withdrawal. After that, she became free from all the aches and the other symptoms, including
became free from the colitis without any other medication, for the first time in many years. Her Optic
Nerve’s disks show only 0,5/1/0/0.25 in both eyes. Her intraocular pressures show 20 mmHg in both
eyes, which made us to increase her eye drops. She was grateful from the treatment.
Here we see the 25 years of sufferings caused by the simultaneous Ocular and Cerebrospinal Fluid
Hypertension, occurring on the same eyes, on the same days, but at different hours. All these sufferings,
including the colitis, were caused by her inherited susceptibility for caffeine, added by taking caffeine
in coffee, soft drinks and medications. These were so long-sufferings, and so easy to cure when
she knew how to do that.
At Scotland, “Eighty-one ulcerative colitis patients were recruited at all stages of the disease process.
Caffeine also has anti-thiamin properties and decaffeinated coffee was associated with a better clinical
state than the caffeine containing version.” (Magee E A, and others).
XVI - 125) Keratoconus. Fetuses' corneal weakening: “Excessive gestational caffeine intake has
been shown histopathologically to have some teratogenic effects on newborn rat cornea (vacuolated endothelial
cells with proliferation, hyperchromasia, polymorphism, endothelial cell agenesis, increased
stromal mitotic activity and focal increase in corneal thickness with widely separated corneal
lamellae).” (Evereklioglu C, and others).
Caffeine (3.5 mg/egg) was administered to chicken embryos: “In experimental groups reduction of
corneal thickness, thickening of corneal epithelium and corneal endothelium as well as Bowman's and
Descemet's membranes, decrease of thickness of corneal stroma in comparison with the control group
have been observed. Caffeine causes thickness changes of all layers and decreases the total thickness of
a developing cornea.” (Kajuwa-Hadrys M, and others).
Probably the keratoconus occurs when the patient have simultaneously:
A- Inherited (genetic) improper caffeine detoxification, mainly by his keratocytes.
B- Her mother drank caffeine during the pregnancy and weakened her baby's cornea, mainly damaging
the corneal keratocytes and stroma. Possibly the caffeine gestational intoxication also caused imperfections
in the fetus corneal Bowman's membrane, which facilitate the caffeine penetration in his stroma.
C- The child also drank daily caffeine, for years along, and without the protection of a healthy Bowman´s
membrane, the caffeine passed from his tears to his corneal stroma, where it progressively killed
his keratocytes and weakened his corneal lamellae.
D- The progressively weakened corneal stroma, with or without its thinning, one day can not stand the