Fluids Hypertension Syndromes: Migraines, Headaches, Normal ...

Fluids Hypertension Syndromes – Dr. Leonardo Izecksohn – page 232
“In New York State women aged 20-49 years (173 matched pairs) in 1975-1980... Both known and
suspected risk factors for bladder cancer were examined for these rare, early-onset female cases. Cases
consumed more coffee per day than did controls.” (Piper J M, and others).
XVI - 29) Bone development inhibition: “Oral caffeine administration to rats implanted with demineralized
bone particles resulted in a dose dependent inhibition of the formation of cartilage tissue in the
implants... Lower doses of 50 and 12.5 mg/kg caffeine also resulted in decreased cellular proliferation
and transformation to cartilage histologically and reflected by significant inhibition of type II collagen
mRNA levels... Thus the observed delayed mineralization in the fetal skeleton associated with caffeine
appears to be related to an inhibition of endochondral bone formation at the early stages of proliferation
of undifferentiated mesenchymal cells to cartilage specific cells as well as at later stages of bone formation.”
(Barone L M, and others).
XVI - 30) Bones weakening and lower bone mass: ''Long-term consumption of caffeinated soft
drinks was negatively associated with (bones) polar strength strain index and periosteal circumference,
which reflect bone modeling.'' (Libuda L, and others).
On “Four clinical centers in Baltimore, Maryland; Minneapolis, Minnesota; Portland, Oregon; and
the Monongahela valley, Pennsylvania... A total of 9704 ambulatory, nonblack women, ages 65 years or
older... Gastric surgery, age, history of maternal fracture, smoking, and caffeine intake were associated
with lower bone mass.” (Bauer D C, and others).
“Dietary intakes of 359 men and 358 women (aged 72 years), participants of the Prospective Investigation
of the Vasculature in Uppsala Seniors, were assessed... Two years later...Men consuming 4 cups
of coffee or more per day had 4% lower Bone mineral density at the proximal femur compared with
low or non-consumers of coffee... In high consumers of coffee, those with rapid metabolism of caffeine
(C/C genotype) had lower Bone mineral density at the femoral neck and at the trochanter than slow
metabolizers (T/T and C/T genotypes). Calcium intake did not modify the relation between coffee and
Bone mineral density.” (Hallstrom H, and others).
XVI - 31) Brain disorders in the fetus and postnatal: “Does the Crick-Mitchison theory suggest if a
drug could interfere with rapid eye movement sleep and cross the placental barrier, then that drug
might cause developmental brain disorders in the fetus? Should all pregnant women completely avoid
caffeine or any agent that might disrupt serotonergic or cholinergic systems?” (Brown D W).
“Chronic caffeine intake during rapid periods of growth (on rats) influences various parts of the brain
in entirely different biochemical manners.”(Yazdani M, and others).
“These results suggest that postnatal caffeine treatment (on mice) might induce an alteration of astrocytogenesis
via A2aR blockade during brain development. … Postnatal caffeine treatment could have
long-term consequences on brain function.” (Desfrere L, and others).
XVI - 32) Breast cancer. Atypical hyperplasia of Benign Breast Disease:
“Circulating estrogens and androgens are important factors in the development of various female cancers...
In 524 premenopausal and 713 postmenopausal women from the Nurses' Health Study... caffeine
may alter circulating levels of luteal estrogens and sex hormone-binding globulin, representing possible
mechanisms by which coffee or caffeine may be associated with pre- and postmenopausal malignancies,
respectively.”(Kotsopoulos J, and others).
“High caffeine consumption was positively associated with risk of atypical hyperplasia of Benign
Breast Disease”. (Webb P M and others).
Studying 14,593 Norwegian women then aged 35 to 49 years, “among the leaner women (body mass
index less than 24), those who drank five or more cups of coffee per day had a 50% decrease in risk of
breast cancer, as compared with those who drank two cups or less. Among the heavier subjects, the opposite
relationship was observed: the women who drank the most coffee showed a twofold increase in
risk.” (Vatten LJ, and others).