Fluids Hypertension Syndromes: Migraines, Headaches, Normal ...

Fluids Hypertension Syndromes – Dr. Leonardo Izecksohn – page 204
XIII- m - Cerebrospinal Fluid Hypertension squeezing the Brain, the Spinal Cord and the Pituitary
gland: The Cerebrospinal Fluid Hypertension also squeezes the Brain, the Spinal Cord, their arteries
and veins, and the Pituitary gland. Probably this squeeze repeated hundreds or thousands times, added
by the toxic effect of caffeine, cause definitive White and Gray Matter damage, which manifest
after many years as definitive Neuropathies. Which are they?
Alzheimer´s disease?
Amyotrophic Lateral Sclerosis?
Cerebellar stroke?
Cerebral Infarction, white and gray matter damage and decrease?
Cerebral Small Vessel Disease?
Empty Sella Turcica Syndrome.
Epilepsy?
Galactorrhea-Amenorrhea?
Hereditary cerebral amyloid angiopathy?
Multiple Sclerosis?
Pituitary hormonal disturbs and Hypothyroidism?
Other? All of them?
We suppose that the first occurrences of these sicknesses and their relapsing are consequent to many
years of daily drinks of caffeine, beer, wine, or excessive water. These brain and spinal chord damage
also can be caused by ischemia, which occurs mainly on the migraines with aura. Here are some of
them:
1 - Alpha rhythm changes: “The accumulated burden of migraine caused slight alterations in the
physiology of the visual cortex. Small alpha rhythm changes were observed along the migraine cycle.”
(Bjork M H, and others).
2 - Alzheimer disease: There are hypothesis correlating Alzheimer disease with Open Angle Glaucoma
and Normal tension Glaucoma, from Suzuki J, and from Tamura H.
Wostyn P, supposes that the etiology of Alzheimer disease is the cumulative and repeated rise of
Cerebrospinal Fluid pressure when the patient does Valsalva maneuvers. The Valsalva maneuver is one
etiology of acute Ocular and Cerebrospinal Fluid Hypertension.
On “27 individuals at risk for familial Alzheimer's disease… Twenty-three subjects were at risk for
PSEN1 mutations and 4 for an APP substitution… Mutation carriers were more likely to report significant
recurrent headache than non-mutation-carrying (67% vs. 25%). Forty percent of mutation carriers
had headaches that met criteria for migraine whereas 17% of non-mutation-carrying met such criteria.
In this population, headache was more common in nondemented familial Alzheimer's disease
mutation carriers than non-mutation-carrying.” (Ringman J M, and others).
“A high prevalence of Cerebrovascular disease and Alzheimer's disease in patients shunted for
idiopathic normal-pressure hydrocephalus; ... The findings support the perception of Idiopathic Normal-pressure
Hydrocephalus as a multiaetiological clinical entity, possibly overlapping pathophysiologically
with Cerebrovascular disease and Alzheimer's disease.”(Bech-Azeddine and others).
Some authors correlated Glaucoma with Alzheimer disease: “Visual field defects and/or optic disk
cupping compatible with the diagnosis of glaucoma were found in 29 out of 112 patients with
Alzheimer’s disease (25.9%)” (Bayer AU, Ferrari F, and Erb C).
“Our results suggest that in patients affected by ocular hypertension, glaucoma, demyelinating optic
neuritis, and Alzheimer's disease there is a reduction of (ocular) Nerve Fiber Layer thickness” (Parisi
V).
“The IL-1α (-889) T allele polymorphism, previously shown to increase IL-1 gene expression, (which
has been associated with an elevated risk of Alzheimer's disease), may be a risk factor in the development
of primary open angle glaucoma.” (Wang C-Y, and others).