Fluids Hypertension Syndromes: Migraines, Headaches, Normal ...

Fluids Hypertension Syndromes – Dr. Leonardo Izecksohn – page 288
XVII- 25 -Cancer cells induction to death: “We found that 8-nitrocaffeine and its analog, which are
candidate radiosensitizers for cancer therapy, induced exclusively caspase-independent necrotic cell
death in cell lines such as U937, HL-60, K562 and Jurkat. The 8-nitrocaffeine-induced necrotic cell
death was mediated by reactive oxygen species... Since cancer cells are often derived from a selected
population of cells resistant to apoptosis, inducers of necrotic cell death could be beneficial to kill cancer
cells that have acquired resistance to apoptosis-induction therapy.” (Naito M, and others).
XVII- 26 -Colon cancer: “Caffeine significantly inhibits adenosine-induced hypoxia-inducible factor-
1alpha protein accumulation in cancer cells. Caffeine also significantly inhibits the A3 receptor-stimulated
cell migration of colon cancer cells.”(Merighi S, and others).
XVII- 27 -Endometrial cancer: “In a population-based prospective cohort study in 53,724 Japanese
women aged 40-69 years with no history of cancer at baseline in 1990-1994... During the 15-year follow-up
period, we documented 117 cases of endometrial cancer. Coffee consumption was significantly
associated with a decreased risk of endometrial cancer.” (Shimazu T, and others).
XVII- 28 -Hepatocellular cancer: “We found that caffeine inhibited the proliferation of hepatocellular
carcinoma cells via cell cycle arrest independent of apoptosis… Our data reveal that caffeine could be a
promising candidate for the treatment of patients with hepatocellular carcinoma.” (Okano J, and
others).
XVII- 29 - Ovarian cancer: Caffeine lowers the risk of ovarian cancer, but only for women that do
not use hormones: “An inverse association was observed between caffeine intake and ovarian cancer
risk, particularly in women not using hormones.” (Tworoger S S, Gertig D M, Gates M A, Hecht J L,
and Hankinson S E). Green tea lowers the risk of ovarian cancer: “Women who reported drinking
>/=1 cup/d of green tea had a 54% reduction in risk”. (Song Y J, and others).
XVII- 30 -Sarcoma and melanoma cancer: “Caffeine, which has a DNA-repair inhibiting effect, enhances
the cytocidal effects of anticancer drugs and radiation…Caffeine-potentiated chemotherapy resulted
in a favourable radiographic response and prolonged overall survival of the patients at all stages
(on chemotherapy for high-grade soft tissue sarcoma).” (Takeuchi A, and others).
“On mice…the A2 receptors antagonists ZM241,385 and caffeine were found to enhance the antitumor
effects of CD8 + T cells in studies of anti-CMS4 sarcoma CD8 + T cells in a lung metastasis
model.” “Treatment with caffeine inhibits neovascularization and increases apoptosis of CL8-1 melanoma
in mice.” “It is shown that ZM241,385 (or caffeine; data not shown) significantly delayed CL8-1
growth in WT (white?) mice, which developed anti-CL8-1 CD8 + T cells.” “…treatment with 1 ´ 10 6
CTL plus caffeine dramatically decreased the number of lung metastasis in mice on day 24.” “Our experiments
may thus provide a molecular explanation for sporadic reports of anticancer properties of
caffeine…”(Ohta A, and others).
“The osteosarcoma-bearing rats were treated with cisplatin and caffeine. The most growth inhibition
was observed in the co-administration group. When three different dosing schedules of caffeine
were given, the extent of tumor inhibition was closely correlated with the average plasma concentration
of caffeine. The cisplatin concentration in the tumor was significantly increased when caffeine was coadministered.
This study confirms that a high concentration of caffeine (about 0.4 mM) is effective in
enhancing the antitumor effects of cisplatin.” (Kawahara M, and others).
XVII- 31 - Skin cancer: “Our studies indicate that caffeine and caffeine sodium benzoate may be useful
as novel inhibitors of sunlight-induced skin cancer.” (Conney A H, and others). “Caffeine and
Theophylline have been shown to exert anticancer activities in both cell culture and animal models.
Meanwhile, 1-ethyl-3-hexylxanthine (xanthine 70) was the most effective compound for inhibiting
epidermal growth factor induced neoplastic transformation.” (Rogozin E A, and others). This
“xanthine 70” is not yet used as a medication.