Fluids Hypertension Syndromes: Migraines, Headaches, Normal ...

Fluids Hypertension Syndromes – Dr. Leonardo Izecksohn – page 249
central activation of both adrenergic and dopaminergic receptors via release of endogenous catecholamines
that leads to behavioral excitation and hyperthermia in rats.” (Lin M T, and others).
XVI - 116) Hyperthyroidism. Hypothyroidism. We had many patients that besides other sicknesses
of the caffeine intoxication, presented hyperthyroidism or hypothyroidism. They were been medicated
for these thyroid disturbs, but although they were taking caffeine or theobromine daily, the physicians
forgot to prescribe its eschew. We conclude that the caffeine is a toxin to the thyroid.
XVI - 117) Hypochondriasis: “Patients with hypochondriasis should eat 3 meals per day to feel as
healthy as possible. They should avoid substances that adversely affect mood, exacerbate anxiety
symptoms, or reduce the quality of sleep (eg, caffeine, alcohol, nicotine).” (Xiong G L, and Bourgeois
J A).
XVI - 118) Inflammatory markers increased. Higher adiponectin:
“Compared with coffee nondrinkers, men who consumed >200 milliliters of coffee/day had:
50% higher interleukin 6,
30% higher C-reactive protein,
12% higher serum amyloid-A,
28% higher tumor necrosis factor A concentrations and
3% higher white blood cell counts.”
“Women who consumed >200 milliliters of coffee/day had:
54% higher interleukin 6,
38% higher C-reactive protein,
28% higher serum amyloid-A,
28% higher tumor necrosis factor A concentrations and
4% higher white blood cell counts than did coffee nondrinkers.”
“Conclusions: A relation exists between moderate-to-high coffee consumption and increased inflammation
process. This relation could explain, in part, the effect of increased coffee intake on the cardiovascular
system.” (Zampelas A, and others).
XVI - 119) Insomnia. Sleep disturbance.
“(1) Habitual caffeine consumption is associated with reduced sleep quality in self-rated caffeine-sensitive
individuals, but not in caffeine-insensitive individuals;
(2) The distribution of distinct c.1083T>C genotypes of the adenosine A2A receptor gene (ADORA2A)
differs between caffeine-sensitive and -insensitive adults; and
(3) The ADORA2A c.1083T>C genotype determines how closely the caffeine-induced changes in brain
electrical activity during sleep resemble the alterations observed in patients with insomnia.” (Rétey J V,
and others).
XVI - 120) Insulin sensitivity reduced. Insulin resistance: “Insulin levels were significantly higher
(by 1.80 microU/ml) after caffeine intake than after placebo. The homeostasis model assessment index
of insulin sensitivity was reduced by 35% by caffeine... Daily caffeine intake reduces insulin sensitivity;
the effect persists for at least a week and is evident up to 12 hours after administration.” (MacKenzie
T, and others).