Fluids Hypertension Syndromes: Migraines, Headaches, Normal ...

Fluids Hypertension Syndromes – Dr. Leonardo Izecksohn – page 247
XVI - 102) Genital Hyperesthesia. The patient with allodynia can present many assorted and strange
aching symptoms. Here is one, between many others: “We report both a female and a male patient in
whom caffeine intake was associated with genital hyperesthesia.” (Markos A R).
XVI - 103) Gestational Diabetes Mellitus worsening: “In the gestational diabetes mellitus group,
glucose area under the curve was greater, C-peptide area under the curve was greater, and insulin sensitivity
index was lower (18%) after caffeine than after placebo. (Robinson L E, and others).
XVI - 104) Glaucomatous inherited tendency. Weakening of the Optic nerve disc during the fetus
formation: As the caffeine weakens the fetus' cornea, probably it weakens also the Optic nerve´s lamina
cribosa, and this causes an increased tendency to the glaucomatous lesion of the Optic nerve.
“Central corneal thickness was found to be a powerful predictor for the development of primary openangle
glaucoma.” (Gordon M O, and others)..
XVI - 105) Glottis edema? Angioneurotic hereditary edema: It is inherited as an autosomal dominant
trait. Its main etiology is a genetic absence of the activity of C1 esterase inhibitor (of the complement
system) in the patient's serum. Its main symptom is an acute swelling in any part of the body. It is
a very rare condition in an ophthalmological office like our one. The few patients who referred this
eventual condition, and survived to tell us this, all were plenty with caffeine, and they presented some
signs and symptoms of the caffeine intoxication. As the caffeine also cause edemas everywhere, we
teach them to stop the caffeine, and until we know, they did not have other bouts of glottis edema or
other edemas. But how much time is it necessary without relapsing the glottis edema to say that the patient
is cured? Evidently, whether the patient drinks the caffeine again, he can relapse his glottis edema
anytime, and this time it can be fatal.
“A 50-year-old man with no relevant medical history emergently presented with acute angioedema of
the lower lip, without urticaria. The inflammation spread to other facial structures but gradually dissipated
after subcutaneous epinephrine was administered... Five days later... the angioedema recurred, and
the patient acted to reverse the attack. Instant coffee was identified as the trigger.”(Larkin K J).
XVI - 106) Graves’ disease: As every smoker knows, smoking is a strong stimulus to drink caffeine,
and caffeine is a stress-maker.
“Smoking has been implicated in the worsening of Graves’ ophthalmopathy”. “Stress can be a factor
for thyroid autoimmunity. Acute stress-induced immunosuppression may be followed by immune system
hyperactivity, which could precipitate autoimmune thyroid disease.” (Yeung, S C J, and others).
We suppose that the caffeine causes the excessive stress, which Dr. Yeung says that causes the thyroid
autoimmunity sickness, and also that caffeine is a toxin to the thyroid cells.
XVI - 107) Hallucinations and Delirium: “The drug is a decided cerebral excitant, stimulating the
mental function, occasioning wakefulness, and under large doses producing hallucinations and delirium.
Caffeine renders the reasoning and imaginative powers more acute, enabling the person to perform
increased and prolonged mental work. Rarely, the ability to take in ideas is increased, and there is a
heightened power of association of ideas.” (Butler G F).
XVI - 108) Heartburn: “Methylxanthines... are able to slightly reduce the tone of the lower esophageal
sphincter. This is of little concern in the normal individual, but in patients with a reduced initial
tone it might lead to heartburn.” (Fredholm B B).
XVI - 109) Heart mitochondria lesions in newborn rats: “Litters of rats were combined upon birth.
Dams with pups... received the diet supplemented with caffeine (4 mg/100 g body weight)... Transmission
electron microscopy revealed swollen, disrupted, degenerating mitochondria and intracellular edema
in the hearts of rats in the caffeine groups... Plasma copper concentration was significantly decreased.
These results indicate that early exposure to caffeine through maternal milk adversely affects
cardiac mitochondria of rat pups and may be associated with decreased plasma copper levels.”