Fluids Hypertension Syndromes: Migraines, Headaches, Normal ...

Fluids Hypertension Syndromes – Dr. Leonardo Izecksohn – page 250
“Caffeinated (5 mg/kg) coffee with the high glycemic index meal (providing 75 g of carbohydrate)
resulted in 147%, 29%, and 40% greater areas under the curve for glucose, insulin, and C-peptide, respectively,
compared with the values for decaffeinated coffee. Similarly, with the low glycemic index
treatment, caffeinated coffee elicited 216%, 44%, and 36% greater areas under the curve for glucose,
insulin, and C-peptide, respectively. Insulin sensitivity was significantly reduced (40%) with the high
glycemic index treatment after caffeinated coffee was ingested compared with decaffeinated coffee;
with the low glycemic index treatment, caffeinated coffee ingestion resulted in a 29% decrease in insulin
sensitivity. The ingestion of caffeinated coffee with either a high or low glycemic index meal significantly
impairs acute blood glucose management and insulin sensitivity compared with ingestion of
decaffeinated coffee.” (Moisey L L, and others).
“During pregnancy...from 251 fasting subjects at mean gestational age of 20.3 ± 2.0 weeks...Caffeine
concentrations in the upper two quartiles (> 266 ng/ml) were associated with threefold higher odds of
having higher insulin resistance (third quartile odds ratio [OR], 3.02; ... and fourth quartile OR, 2.95).
Paraxanthine concentrations in the upper quartile (> 392 ng/ml) were also associated with threefold
higher odds of having higher insulin resistance (OR, 3.04). Both high caffeine and paraxanthine concentrations
were associated with insulin resistance, but slow versus fast metabolism did not make an
important difference.” (Laughon S K and others).
XVI - 121) Interstitial cystitis/Painful bladder syndrome: “Stimulatory foods, anorectal disease and
caffeine beverages are potential risk factors for interstitial cystitis/painful bladder syndrome.” (Li G Z,
and others).
XVI - 122) Interstitial nephritis chronic and other sicknesses consequent to analgesics (with caffeine?):
“In a group of 274 urological patients... The reason for chronic consumption of analgesics is
mainly headache... After an average latency period of 20 years, renal (papillary necrosis, chronic interstitial
nephritis) and extrarenal manifestations appeared. Despite slow progression and low gradient
symptoms, severe alterations could be determined at the first examination. In the last decade, an increase
of transitional cell carcinoma induced by analgesics has been observed. 22 of our patients
presented a tumor of the urothelium (i.e. 8%). A further increase of these specific cases is expected.”
(Porpáczy P).
XVI - 123) Irritability: It is caused by the caffeine intoxication, besides other etiologies.
XVI - 124) Irritable bowel syndrome (Ulcerative Colitis) (Chronic diarrhea): It occurs together with
the Ocular and Cerebrospinal Fluids Hypertension Syndromes, until advanced Glaucoma. All patients
we saw were consequent to the caffeine. Here is one patient: