Fluids Hypertension Syndromes: Migraines, Headaches, Normal ...

Fluids Hypertension Syndromes – Dr. Leonardo Izecksohn – page 272
Rheumatoid Arthritis and caffeine: We had a beautiful Mulatta, 28-year-old, 1.66 meters (5 feet
and 5 inches) tall, 60 Kilograms (132 pounds), working with children recreation, two children. Her
great-grandfathers and great-grandmothers were European, Black, and Indian. She used to drink coffee
500 milliliter (one pint) and caffeinated soft drinks 1.000 milliliter (two pints) daily, for the last 10
or more years. She had suffered with “allergic otitis”, “allergic rhinitis”, “allergic sinusitis and
Pharyngitis” all these years, without the medical doctors identifying any specific etiology. She suffered
many therapies without cure. Six months ago she presented spread Rheumatoid Arthritis, and now she
takes eight different medications daily, and is preparing to add one more. Her eyes presented intraocular
pressures of 12 and 14 mmHg (physiologic). Almost her entire eyes examination was physiologic.
On her direct ophthalmoscopy, we found only small increase of the Optic Nerves’ cups, with 0.6/3/1/0
and 0.5/3/1/0 right and left eyes (Cup diameter/ cup depth/ lamina cribosa’s pores visibility/ borders
edema), which characterizes the Ocular Hypertension Syndrome, which explains the old “allergic Otitis,
rhinitis, sinusitis and Pharyngitis”.
Was the Rheumatoid Arthritis stimulated by the excessive caffeine she drank all those years, added
with her personal inherited susceptibility? Is there a pathological stimulus to the immunologic system
caused by the caffeine?
Cloroquine doesn't cure. Withdrawal of caffeine cures: We had a 74 year-old Brazilian White
house-wife, 2 children, weighting 58 kilograms (128 pounds), with 1.53 meter tall (5 feet). Her father
was Portuguese white, her mother was mulatta. Her sufferings began more than 10 years before, with
legs aches at night and morning, everyday. Her aches worsened and spread to almost all her joints,
with bi-temporal headaches, precordial angina, legs and back aches. All aches were so strong that she
could no more walk, and she wore wheelchair. On December 2007, she begun to medicate with
Chloroquine, 400 mg each day, which made her feel a little better. On February 2009, she came limping
in our office, supported by a granddaughter, in order to control the eye's toxicity of chloroquine.
She was a daily drinker of caffeinated colas, maté 400 milliliters (nearly 1 pint), and coffee 150 milliliters
(5 fluid ounces). For improving her aches, she medicated with caffeinated analgesics. Besides
other exams, we taught her to stop all caffeine at once. She decided to stop also the chloroquine,
without any advise to do this.
Now, after only 1 month, she came walking straight, without any of her old strong aches. All those
sufferings were past. There remained few and small aches, which doesn't bother her. Even the precordial
angina reduced. She told us that she suffered the first week of aches from caffeine's withdrawal, but
was strong enough to sustain it. Now she is cured, without chloroquine. Her Rheumatoid doctor became
very admired.
Caffeine reversed the effect of methotrexate: “Weekly low-dose methotrexate remains the mainstay
of second-line therapy for rheumatoid arthritis...Neither theophylline alone nor caffeine alone
(each at 10 mg/kg/day) significantly affected the severity of the arthritis, but both agents markedly reversed
the effect of methotrexate.” (Montesinos M C, and others).
XVI - 206) Schizophrenia, schizoaffective disorder, mania, and depression.
“People with schizophrenia typically consume large amounts of caffeine.” (Lande R G).
“Among caffeine consumers, heavy caffeine intake (> or =200 mg/day) was significantly associated
with schizophrenia (64%). (Gurpegui M, and others).
“If their theory is correct then abnormalities of reverse learning might account for some aspects of
schizophrenia, mania, and depression.”(Brown D W).
“Schizophrenia/schizoaffective disorder group had two times greater serum caffeine levels as compared
to smokers without any mental illness with similar smoking behavior.”(Gandhi K K, and others).
“Caffeine, 10 mg/kg, was administered to 13 schizophrenic patients in a double-blind placebo-controlled
study of its behavioral effects. Some measures of psychopathology were significantly increased:
Brief Psychiatric Rating Scale (BPRS) total, BPRS subscales thought disorder, unusual thought content,
and euphoria-activation, and several individual BPRS items. Nurses' Bunney-Hamberg ratings of
psychosis and mania, comparing the day before with the day after pharmacological challenge, in-