Fluids Hypertension Syndromes: Migraines, Headaches, Normal ...

Fluids Hypertension Syndromes – Dr. Leonardo Izecksohn – page 244
“A significant increase in the risk of infertility due to tubal disease or endometriosis was observed for
the upper levels of caffeine intake, indicating a threshold effect. For tubal infertility, a relative risk of
1.5 was found in women who consumed more than 7 g of caffeine per month as compared with those
who consumed 3 g or less per month. For endometriosis, the relative risk was 1.9 in women who consumed
5.1-7 g/month and 1.6 in those with an intake of more than 7 g/month.” (Grodstein F, and others).
XVI - 88) Fetus of mice abnormalities:
“Even most commonly consumed beverages like tea, coffee, chocolate and cocoa contain methylxanthines,
biogenic amines and polyphenols, among them catechins, that exhibit significant biological
activity and might profoundly affect the organism homeostasis. We have previously shown that 400 mg
of bitter chocolate or 6 mg of theobromine added to the daily diet of pregnant and afterwards lactating
mice affected embryonic angiogenesis and caused bone mineralization disturbances as well as
limb shortening in 4-weeks old offspring. The aim of the present study was the morphometric and
functional evaluation of kidneys in the 4-weeks old progeny mice fed according to the protocol mentioned
above. Progeny from the mice fed chocolate presented considerable morphometric abnormalities
in the kidney structure, with the lower number of glomeruli per mm2 and their increased diameter.
Moreover, higher serum creatinine concentration was observed in that group of offspring.”(Patera J,
and others).
XVI - 89) Fetus underdevelopment. Small-for-gestational-age infants. Lower birth weight. Prematurity.
Placental abruption. Reduced head circumference. Neurobehavioral effects. Infant somatic
development alteration. Stillbirths.:
“A high caffeine intake in the third trimester may be a risk factor for fetal growth retardation, in particular
if the fetus is a boy.” (Vik T, and others).
“Since caffeine crosses the placenta and is metabolized by the fetus very slowly, the fetus may be at
risk of exposure to significant amounts of caffeine from its mother. In animal studies, high doses of caffeine
cause skeletal birth defects, retarded fetal growth, reduced birth weight, and increased stillbirths
while lower doses equivalent to only two cups coffee/day may cause slowed bone growth. Subtle neurobehavioral
effects persisting into adulthood have been reported in rats exposed to modest doses of caffeine.
Caffeine consumed by males prior to mating can also produce significant fetal growth retardation.”
“Some population studies have shown that high levels of caffeine intake by pregnant women are associated
with a higher than normal incidence of prematurity, lower birth weights, and reduced head circumference.
Based on available data, the Food and Drug Administration has advised pregnant women
to avoid all caffeine during pregnancy.” (Andrews University Nutrition Department).
“Results from this study support previously published results from this group of monkeys indicating
that caffeine consumption during pregnancy can alter infant somatic development.” (Gilbert S G, and
Rice D C).
XVI - 90) Fibrocystic breast disease and breast pain:
“138 patients with fibrocystic breast disease… and with breast pain… were counseled to abstain from
or reduce caffeine consumption. The results at the end of one year indicated that compliance was high,
with 113 patients (81.9 percent) reducing their caffeine intake substantially and, of those, 69 (61 percent)
reporting a decrease or absence of breast pain.” (Russell L C).
XVI - 91) Flushing of the face: It is caused by the caffeine intoxication, besides other etiologies.
XVI - 92) Fractures in the elderly: “Due to age-associated bone losses, all elderly are prone to osteoporosis,
which often leads to fractures. Fractures frequently result in dependency and institutionalization,
as well as physical deformities that may lead to respiratory and cardiovascular problems. Thus
care of the elderly focuses primarily on lifestyle modification and increased dietary intake of calcium
and vitamin D; decreased intake of caffeine, phosphates, and alcohol;…” (O’Connell M B.)